1mu8: Difference between revisions

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[[Image:1mu8.jpg|left|200px]]
{{Seed}}
[[Image:1mu8.png|left|200px]]


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{{STRUCTURE_1mu8|  PDB=1mu8  |  SCENE=  }}  
{{STRUCTURE_1mu8|  PDB=1mu8  |  SCENE=  }}  


'''thrombin-hirugen_l-378,650'''
===thrombin-hirugen_l-378,650===




==Overview==
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Recent efforts in the field of thrombin inhibitor research have focused on the identification of compounds with good oral bioavailability and pharmacokinetics. In this manuscript we describe a metabolism-based approach to the optimization of the 3-(2-phenethylamino)-6-methylpyrazinone acetamide template (e.g., 1) which resulted in the modification of each of the three principal components (i.e., P1, P2, P3) comprising this series. As a result of these studies, several potent thrombin inhibitors (e.g., 20, 24, 25) were identified which exhibit high levels of oral bioavailability and long plasma half-lives.
The line below this paragraph, {{ABSTRACT_PUBMED_12570369}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 12570369 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12570369}}


==About this Structure==
==About this Structure==
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[[Category: Yan, Y.]]
[[Category: Yan, Y.]]
[[Category: Thrombin-hirugen]]
[[Category: Thrombin-hirugen]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 01:43:08 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:39:21 2008''
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