1mug: Difference between revisions

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[[Image:1mug.gif|left|200px]]
{{Seed}}
[[Image:1mug.png|left|200px]]


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{{STRUCTURE_1mug|  PDB=1mug  |  SCENE=  }}  
{{STRUCTURE_1mug|  PDB=1mug  |  SCENE=  }}  


'''G:T/U MISMATCH-SPECIFIC DNA GLYCOSYLASE FROM E.COLI'''
===G:T/U MISMATCH-SPECIFIC DNA GLYCOSYLASE FROM E.COLI===




==Overview==
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G:U mismatches resulting from deamination of cytosine are the most common promutagenic lesions occurring in DNA. Uracil is removed in a base-excision repair pathway by uracil DNA-glycosylase (UDG), which excises uracil from both single- and double-stranded DNA. Recently, a biochemically distinct family of DNA repair enzymes has been identified, which excises both uracil and thymine, but only from mispairs with guanine. Crystal structures of the mismatch-specific uracil DNA-glycosylase (MUG) from E. coli, and of a DNA complex, reveal a remarkable structural and functional homology to UDGs despite low sequence identity. Details of the MUG structure explain its thymine DNA-glycosylase activity and the specificity for G:U/T mispairs, which derives from direct recognition of guanine on the complementary strand.
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{{ABSTRACT_PUBMED_9489705}}


==About this Structure==
==About this Structure==
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[[Category: Savva, R.]]
[[Category: Savva, R.]]
[[Category: Dna-glycosylase]]
[[Category: Dna-glycosylase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 01:43:46 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:43:51 2008''

Revision as of 14:43, 28 July 2008

File:1mug.png

Template:STRUCTURE 1mug

G:T/U MISMATCH-SPECIFIC DNA GLYCOSYLASE FROM E.COLI

Template:ABSTRACT PUBMED 9489705

About this Structure

1MUG is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of a G:T/U mismatch-specific DNA glycosylase: mismatch recognition by complementary-strand interactions., Barrett TE, Savva R, Panayotou G, Barlow T, Brown T, Jiricny J, Pearl LH, Cell. 1998 Jan 9;92(1):117-29. PMID:9489705

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