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| [[Image:1muj.gif|left|200px]] | | {{Seed}} |
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| {{STRUCTURE_1muj| PDB=1muj | SCENE= }} | | {{STRUCTURE_1muj| PDB=1muj | SCENE= }} |
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| '''Crystal structure of murine class II MHC I-Ab in complex with a human CLIP peptide'''
| | ===Crystal structure of murine class II MHC I-Ab in complex with a human CLIP peptide=== |
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| ==Overview==
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| Association between the class II major histocompatibility complex (MHC) and the class II invariant chain-associated peptide (CLIP) occurs naturally as an intermediate step in the MHC class II processing pathway. Here, we report the crystal structure of the murine class II MHC molecule I-A(b) in complex with human CLIP at 2.15A resolution. The structure of I-A(b) accounts, via the peptide-binding groove's unique physicochemistry, for the distinct peptide repertoire bound by this allele. CLIP adopts a similar conformation to peptides bound by other I-A alleles, reinforcing the notion that CLIP is presented as a conventional peptide antigen. When compared to the related HLA-DR3/CLIP complex structure, the CLIP peptide displays a slightly different conformation and distinct interaction pattern with residues in I-A(b). In addition, after examining the published sequences of peptides presented by I-A(b), we discuss the possibility of predicting peptide alignment in the I-A(b) binding groove using a simple scoring matrix.
| | The line below this paragraph, {{ABSTRACT_PUBMED_12589760}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 12589760 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_12589760}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: I-ab]] | | [[Category: I-ab]] |
| [[Category: Peptide]] | | [[Category: Peptide]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:44:17 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:34:04 2008'' |
