8u4v: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry 8u4v is ON HOLD~~

==Cryo-EM structure of human claudin-4 complex with Clostridium perfringens enterotoxin C-terminal domain, sFab COP-1, and Nanobody==

~~Authors: Vecchio, A.J.~~

== Structural highlights ==

<table><tr><td colspan='2'>[[8u4v]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_perfringens Clostridium perfringens], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8U4V OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=8U4V FirstGlance].

~~Description:~~ Cryo-EM structure of human claudin-4 complex with Clostridium perfringens enterotoxin C-terminal domain, sFab COP-1, and Nanobody

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.99Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AV0:2-decyl-2-{[(4-O-alpha-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]methyl}dodecyl+4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside'>AV0</scene></td></tr>

[[Category: Vecchio~~, A.J~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=8u4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8u4v OCA], [https://pdbe.org/8u4v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8u4v RCSB], [https://www.ebi.ac.uk/pdbsum/8u4v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8u4v ProSAT]</td></tr>

</table>

== Disease ==

[https://www.uniprot.org/uniprot/CLD4_HUMAN CLD4_HUMAN] CLDN4 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.

== Function ==

[https://www.uniprot.org/uniprot/CLD4_HUMAN CLD4_HUMAN] Channel-forming tight junction protein that mediates paracellular chloride transport in the kidney. Plays a critical role in the paracellular reabsorption of filtered chloride in the kidney collecting ducts. Claudins play a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.[UniProtKB:O35054]

__TOC__

</StructureSection>

[[Category: Clostridium perfringens]]

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Synthetic construct]]

[[Category: Vecchio AJ]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8u4v is ON HOLD
+==Cryo-EM structure of human claudin-4 complex with Clostridium perfringens enterotoxin C-terminal domain, sFab COP-1, and Nanobody==
+<StructureSection load='8u4v' size='340' side='right'caption='[[8u4v]], [[Resolution|resolution]] 2.99&Aring;' scene=''>
-Authors: Vecchio, A.J.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8u4v]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_perfringens Clostridium perfringens], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8U4V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8U4V FirstGlance]. <br>
-Description: Cryo-EM structure of human claudin-4 complex with Clostridium perfringens enterotoxin C-terminal domain, sFab COP-1, and Nanobody
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.99&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AV0:2-decyl-2-{[(4-O-alpha-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]methyl}dodecyl+4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside'>AV0</scene></td></tr>
-[[Category: Vecchio, A.J]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8u4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8u4v OCA], [https://pdbe.org/8u4v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8u4v RCSB], [https://www.ebi.ac.uk/pdbsum/8u4v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8u4v ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/CLD4_HUMAN CLD4_HUMAN] CLDN4 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.
+== Function ==
+[https://www.uniprot.org/uniprot/CLD4_HUMAN CLD4_HUMAN] Channel-forming tight junction protein that mediates paracellular chloride transport in the kidney. Plays a critical role in the paracellular reabsorption of filtered chloride in the kidney collecting ducts. Claudins play a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.[UniProtKB:O35054]
+__TOC__
+</StructureSection>
+[[Category: Clostridium perfringens]]
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Synthetic construct]]
+[[Category: Vecchio AJ]]