1muq: Difference between revisions

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[[Image:1muq.~~gif~~|left|200px]]

[[Image:1muq.png|left|200px]]

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~~'''~~X-ray Crystal Structure of Rattlesnake Venom Complexed With Thiodigalactoside~~'''~~

===X-ray Crystal Structure of Rattlesnake Venom Complexed With Thiodigalactoside===

~~==Overview==~~

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~~Rattlesnake venom lectin (RSL) from the western diamondback rattlesnake (Crotalus atrox) is an oligomeric galactose~~-~~specific C~~-~~type lectin.~~ The ~~X-ray crystal structure of RSL~~, ~~in complex with lactose and thiodigalactoside~~, at 2.~~2 and 2~~.~~3 A resolution~~, respectively, reveals a decameric protein composed of two 5-fold symmetric pentamers arranged in a staggered, back-to-back orientation. Each monomer corresponds to a single canonical C-type lectin carbohydrate recognition domain devoid of accessory domains and is ~~disulfide-bonded to a monomer in~~ the ~~other pentamer~~. ~~The structure is the first example of that of a carbohydrate complex of a vertebrate galactose~~-~~specific C~~-type lectin. The 10 carbohydrate-binding sites, located on the rim of the decamer, suggest a role for multivalent interactions and a mechanism for RSL's ability to promote receptor cross-linking and cell aggregation.

The line below this paragraph, {{ABSTRACT_PUBMED_15049685}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 15049685 is the PubMed ID number.

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==About this Structure==

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[[Category: Decamer]]

[[Category: Protein-carbohydrate complex]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 01~~:44:40 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:49:42 2008''

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-[[Image:1muq.gif|left|200px]]
+{{Seed}}
+[[Image:1muq.png|left|200px]]
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 {{STRUCTURE_1muq|  PDB=1muq  |  SCENE=  }}
-'''X-ray Crystal Structure of Rattlesnake Venom Complexed With Thiodigalactoside'''
+===X-ray Crystal Structure of Rattlesnake Venom Complexed With Thiodigalactoside===
-==Overview==
+<!--
-Rattlesnake venom lectin (RSL) from the western diamondback rattlesnake (Crotalus atrox) is an oligomeric galactose-specific C-type lectin. The X-ray crystal structure of RSL, in complex with lactose and thiodigalactoside, at 2.2 and 2.3 A resolution, respectively, reveals a decameric protein composed of two 5-fold symmetric pentamers arranged in a staggered, back-to-back orientation. Each monomer corresponds to a single canonical C-type lectin carbohydrate recognition domain devoid of accessory domains and is disulfide-bonded to a monomer in the other pentamer. The structure is the first example of that of a carbohydrate complex of a vertebrate galactose-specific C-type lectin. The 10 carbohydrate-binding sites, located on the rim of the decamer, suggest a role for multivalent interactions and a mechanism for RSL's ability to promote receptor cross-linking and cell aggregation.
+The line below this paragraph, {{ABSTRACT_PUBMED_15049685}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 15049685 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_15049685}}
 ==About this Structure==
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 [[Category: Decamer]]
 [[Category: Protein-carbohydrate complex]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 01:44:40 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:49:42 2008''