1mvh: Difference between revisions

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[[Image:1mvh.~~jpg~~|left|200px]]

[[Image:1mvh.png|left|200px]]

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~~'''~~structure of the SET domain histone lysine methyltransferase Clr4~~'''~~

===structure of the SET domain histone lysine methyltransferase Clr4===

~~==Overview==~~

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~~Methylation of histone H3 lysine 9 is an important component of the 'histone code' for heterochromatic gene silencing.~~ The ~~SET domain-containing Clr4 protein~~, ~~a close relative of Su(var)3-9 proteins in higher eukaryotes~~, ~~specifically methylates lysine 9 of histone H3 and is essential for silencing in Schizosaccharomyces pombe. Here we report~~ the 2.~~3 A resolution crystal structure of the catalytic domain of Clr4~~. ~~The structure reveals an overall fold rich in beta-strands~~, ~~a potential active site consisting of a SAM-binding pocket, and a connected groove that could accommodate~~ the ~~binding of the N-terminal tail of histone H3~~. ~~The pre~~-~~SET motif contains a triangular zinc cluster coordinated by nine cysteines distant from the active site, whereas the post~~-SET region is largely flexible but proximal to the active site. The structure provides insights into the architecture of SET domain histone methyltransferases and establishes a paradigm for further characterization of the Clr4 family of epigenetic regulators.

The line below this paragraph, {{ABSTRACT_PUBMED_12389037}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 12389037 is the PubMed ID number.

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==About this Structure==

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[[Category: Lysine methyltransferase]]

[[Category: Set-domain]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 01~~:46:03 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:20:59 2008''

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-[[Image:1mvh.jpg|left|200px]]
+{{Seed}}
+[[Image:1mvh.png|left|200px]]
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 {{STRUCTURE_1mvh|  PDB=1mvh  |  SCENE=  }}
-'''structure of the SET domain histone lysine methyltransferase Clr4'''
+===structure of the SET domain histone lysine methyltransferase Clr4===
-==Overview==
+<!--
-Methylation of histone H3 lysine 9 is an important component of the 'histone code' for heterochromatic gene silencing. The SET domain-containing Clr4 protein, a close relative of Su(var)3-9 proteins in higher eukaryotes, specifically methylates lysine 9 of histone H3 and is essential for silencing in Schizosaccharomyces pombe. Here we report the 2.3 A resolution crystal structure of the catalytic domain of Clr4. The structure reveals an overall fold rich in beta-strands, a potential active site consisting of a SAM-binding pocket, and a connected groove that could accommodate the binding of the N-terminal tail of histone H3. The pre-SET motif contains a triangular zinc cluster coordinated by nine cysteines distant from the active site, whereas the post-SET region is largely flexible but proximal to the active site. The structure provides insights into the architecture of SET domain histone methyltransferases and establishes a paradigm for further characterization of the Clr4 family of epigenetic regulators.
+The line below this paragraph, {{ABSTRACT_PUBMED_12389037}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12389037 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12389037}}
 ==About this Structure==
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 [[Category: Lysine methyltransferase]]
 [[Category: Set-domain]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 01:46:03 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:20:59 2008''