1mvj: Difference between revisions

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[[Image:1mvj.jpg|left|200px]]
{{Seed}}
[[Image:1mvj.png|left|200px]]


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{{STRUCTURE_1mvj|  PDB=1mvj  |  SCENE=  }}  
{{STRUCTURE_1mvj|  PDB=1mvj  |  SCENE=  }}  


'''N-TYPE CALCIUM CHANNEL BLOCKER, OMEGA-CONOTOXIN MVIIA NMR, 15 STRUCTURES'''
===N-TYPE CALCIUM CHANNEL BLOCKER, OMEGA-CONOTOXIN MVIIA NMR, 15 STRUCTURES===




==Overview==
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The omega-conotoxins are a set of structurally related peptides that have a wide range of specificities for different subtypes of the voltage-sensitive calcium channel (VSCC). To understand their VSCC subtype differentiation we studied the structure of two naturally occurring omega-conotoxins, MVIIA (specific to N-type) and SVIB (specific to P/Q-type) and a synthetic hybrid, SNX-202, which has altered specificities to both VSCC subtypes. The secondary structures of the three peptides are almost identical, consisting of a triple-stranded beta-sheet and several turns. A comparison of NMR data emphasizes the structural similarities between the peptides and highlights some minor structural differences. In the three-dimensional structures of SVIB and MVIIA these are manifested as orientational differences between two key loops. The structural rigidity of MVIIA was also examined. H alpha shifts are similar in a range of solvents, indicating that there are no solvent-induced changes in structure. The omega-conotoxins form a consensus structure despite differences in sequence and VSCC subtype specificity. This indicates that the omega-conotoxin macrosites for the N/P/Q-subfamily of VSCCs are related, with specificity for receptor targets being conferred by the positions of functional side-chains on the surface of the peptides.
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{{ABSTRACT_PUBMED_8913308}}


==About this Structure==
==About this Structure==
1MVJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Conus_striatus Conus striatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MVJ OCA].  
1MVJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Conus_striatus Conus striatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MVJ OCA].  


==Reference==
==Reference==
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[[Category: Conus striatus peptide specific to p/q-type voltage sensitive calcium channel]]
[[Category: Conus striatus peptide specific to p/q-type voltage sensitive calcium channel]]
[[Category: Neurotoxin]]
[[Category: Neurotoxin]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 01:46:18 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:29:35 2008''

Revision as of 13:29, 29 July 2008

File:1mvj.png

Template:STRUCTURE 1mvj

N-TYPE CALCIUM CHANNEL BLOCKER, OMEGA-CONOTOXIN MVIIA NMR, 15 STRUCTURES

Template:ABSTRACT PUBMED 8913308

About this Structure

1MVJ is a Single protein structure of sequence from Conus striatus. Full experimental information is available from OCA.

Reference

A consensus structure for omega-conotoxins with different selectivities for voltage-sensitive calcium channel subtypes: comparison of MVIIA, SVIB and SNX-202., Nielsen KJ, Thomas L, Lewis RJ, Alewood PF, Craik DJ, J Mol Biol. 1996 Oct 25;263(2):297-310. PMID:8913308

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