1mwh: Difference between revisions

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[[Image:1mwh.jpg|left|200px]]
{{Seed}}
[[Image:1mwh.png|left|200px]]


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{{STRUCTURE_1mwh|  PDB=1mwh  |  SCENE=  }}  
{{STRUCTURE_1mwh|  PDB=1mwh  |  SCENE=  }}  


'''REOVIRUS POLYMERASE LAMBDA3 BOUND TO MRNA CAP ANALOG'''
===REOVIRUS POLYMERASE LAMBDA3 BOUND TO MRNA CAP ANALOG===




==Overview==
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The reovirus polymerase and those of other dsRNA viruses function within the confines of a protein capsid to transcribe the tightly packed dsRNA genome segments. The crystal structure of the reovirus polymerase, lambda3, determined at 2.5 A resolution, shows a fingers-palm-thumb core, similar to those of other viral polymerases, surrounded by major N- and C-terminal elaborations, which create a cage-like structure, with four channels leading to the catalytic site. This "caged" polymerase has allowed us to visualize the results of several rounds of RNA polymerization directly in the crystals. A 5' cap binding site on the surface of lambda3 suggests a template retention mechanism by which attachment of the 5' end of the plus-sense strand facilitates insertion of the 3' end of the minus-sense strand into the template channel.
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{{ABSTRACT_PUBMED_12464184}}


==About this Structure==
==About this Structure==
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[[Category: Polymerase-cap analog complex]]
[[Category: Polymerase-cap analog complex]]
[[Category: Right hand configuration]]
[[Category: Right hand configuration]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 01:48:10 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:14:28 2008''

Revision as of 10:14, 28 July 2008

File:1mwh.png

Template:STRUCTURE 1mwh

REOVIRUS POLYMERASE LAMBDA3 BOUND TO MRNA CAP ANALOG

Template:ABSTRACT PUBMED 12464184

About this Structure

1MWH is a Single protein structure of sequence from Reovirus sp.. Full crystallographic information is available from OCA.

Reference

RNA synthesis in a cage--structural studies of reovirus polymerase lambda3., Tao Y, Farsetta DL, Nibert ML, Harrison SC, Cell. 2002 Nov 27;111(5):733-45. PMID:12464184

Page seeded by OCA on Mon Jul 28 13:14:28 2008

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