1mwk: Difference between revisions

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[[Image:1mwk.gif|left|200px]]
{{Seed}}
[[Image:1mwk.png|left|200px]]


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{{STRUCTURE_1mwk|  PDB=1mwk  |  SCENE=  }}  
{{STRUCTURE_1mwk|  PDB=1mwk  |  SCENE=  }}  


'''ParM from plasmid R1 APO form'''
===ParM from plasmid R1 APO form===




==Overview==
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It was the general belief that DNA partitioning in prokaryotes is independent of a cytoskeletal structure, which in eukaryotic cells is indispensable for DNA segregation. Recently, however, immunofluorescence microscopy revealed highly dynamic, filamentous structures along the longitudinal axis of Escherichia coli formed by ParM, a plasmid-encoded protein required for accurate segregation of low-copy-number plasmid R1. We show here that ParM polymerizes into double helical protofilaments with a longitudinal repeat similar to filamentous actin (F-actin) and MreB filaments that maintain the cell shape of non-spherical bacteria. The crystal structure of ParM with and without ADP demonstrates that it is a member of the actin family of proteins and shows a domain movement of 25 degrees upon nucleotide binding. Furthermore, the crystal structure of ParM reveals major differences in the protofilament interface compared with F-actin, despite the similar arrangement of the subunits within the filaments. Thus, there is now evidence for cytoskeletal structures, formed by actin-like filaments that are involved in plasmid partitioning in E.coli.
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{{ABSTRACT_PUBMED_12486014}}


==About this Structure==
==About this Structure==
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[[Category: Plasmid]]
[[Category: Plasmid]]
[[Category: Plasmid partition]]
[[Category: Plasmid partition]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 01:48:21 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:12:00 2008''

Revision as of 12:12, 29 July 2008

File:1mwk.png

Template:STRUCTURE 1mwk

ParM from plasmid R1 APO form

Template:ABSTRACT PUBMED 12486014

About this Structure

1MWK is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

F-actin-like filaments formed by plasmid segregation protein ParM., van den Ent F, Moller-Jensen J, Amos LA, Gerdes K, Lowe J, EMBO J. 2002 Dec 16;21(24):6935-43. PMID:12486014

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