1mxq: Difference between revisions

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[[Image:1mxq.jpg|left|200px]]
{{Seed}}
[[Image:1mxq.png|left|200px]]


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{{STRUCTURE_1mxq|  PDB=1mxq  |  SCENE=  }}  
{{STRUCTURE_1mxq|  PDB=1mxq  |  SCENE=  }}  


'''Solution Structure of the Tachykinin Peptide Eledoisin'''
===Solution Structure of the Tachykinin Peptide Eledoisin===




==Overview==
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Both the aqueous and the lipid-induced structure of eledoisin, an undecapeptide of mollusk origin, have been studied by two-dimensional proton nuclear magnetic resonance spectroscopy and distance geometry calculations. Unambiguous nuclear magnetic resonance assignments of protons have been made with the aid of correlation spectroscopy experiments and nuclear Overhauser effect spectroscopy experiments. The distance constraints obtained from the nuclear magnetic resonance data have been utilized in a distance geometry algorithm to generate a family of structures, which have been refined using restrained energy minimization and dynamics. These data show that, while in water and dimethyl sulfoxide, eledoisin prefers to be in an extended chain conformation, whereas in the presence of perdeuterated dodecylphosphocholine micelles, a membrane model system, helical conformation is induced in the central core and C-terminal region (K4-M11) of the peptide. N terminus, though less defined, also displays some degree of order and a possible turn structure. The conformation adopted by eledoisin in the presence of dodecylphosphocholine micelles is similar to the structural motif typical of neurokinin-2 selective agonists and with that reported for kassinin in hydrophobic environment.
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{{ABSTRACT_PUBMED_12524318}}


==About this Structure==
==About this Structure==
1MXQ is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MXQ OCA].  
1MXQ is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MXQ OCA].  


==Reference==
==Reference==
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[[Category: Helix]]
[[Category: Helix]]
[[Category: Lipid induced conformation]]
[[Category: Lipid induced conformation]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 01:50:48 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:10:41 2008''

Revision as of 18:10, 28 July 2008

File:1mxq.png

Template:STRUCTURE 1mxq

Solution Structure of the Tachykinin Peptide Eledoisin

Template:ABSTRACT PUBMED 12524318

About this Structure

1MXQ is a Single protein structure. Full experimental information is available from OCA.

Reference

Solution structure of the tachykinin peptide eledoisin., Grace RC, Chandrashekar IR, Cowsik SM, Biophys J. 2003 Jan;84(1):655-64. PMID:12524318

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