1mzp: Difference between revisions

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[[Image:1mzp.~~gif~~|left|200px]]

[[Image:1mzp.png|left|200px]]

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~~'''~~Structure of the L1 protuberance in the ribosome~~'''~~

===Structure of the L1 protuberance in the ribosome===

~~==Overview==~~

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The ~~L1 protuberance of~~ the ~~50S ribosomal subunit is implicated in~~ the ~~release~~/~~disposal of deacylated tRNA from the E site~~. ~~The apparent mobility of this ribosomal region has thus far prevented an accurate determination of its three-dimensional structure within either the 50S subunit or the 70S ribosome~~. ~~Here we report~~ the ~~crystal structure at 2~~.~~65 A resolution of ribosomal protein L1 from Sulfolobus acidocaldarius in complex with a specific 55~~-nucleotide fragment of 23S rRNA from Thermus thermophilus. This structure fills a major gap in current models of the 50S ribosomal subunit. The conformations of L1 and of the rRNA fragment differ dramatically from those within the crystallographic model of the T. thermophilus 70S ribosome. Incorporation of the L1-rRNA complex into the structural models of the T. thermophilus 70S ribosome and the Deinococcus radiodurans 50S subunit gives a reliable representation of most of the L1 protuberance within the ribosome.

The line below this paragraph, {{ABSTRACT_PUBMED_12514741}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 12514741 is the PubMed ID number.

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==About this Structure==

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[[Category: Ribosome]]

[[Category: Rna-protein complex]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 01~~:54:32 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:30:39 2008''

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-[[Image:1mzp.gif|left|200px]]
+{{Seed}}
+[[Image:1mzp.png|left|200px]]
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 {{STRUCTURE_1mzp|  PDB=1mzp  |  SCENE=  }}
-'''Structure of the L1 protuberance in the ribosome'''
+===Structure of the L1 protuberance in the ribosome===
-==Overview==
+<!--
-The L1 protuberance of the 50S ribosomal subunit is implicated in the release/disposal of deacylated tRNA from the E site. The apparent mobility of this ribosomal region has thus far prevented an accurate determination of its three-dimensional structure within either the 50S subunit or the 70S ribosome. Here we report the crystal structure at 2.65 A resolution of ribosomal protein L1 from Sulfolobus acidocaldarius in complex with a specific 55-nucleotide fragment of 23S rRNA from Thermus thermophilus. This structure fills a major gap in current models of the 50S ribosomal subunit. The conformations of L1 and of the rRNA fragment differ dramatically from those within the crystallographic model of the T. thermophilus 70S ribosome. Incorporation of the L1-rRNA complex into the structural models of the T. thermophilus 70S ribosome and the Deinococcus radiodurans 50S subunit gives a reliable representation of most of the L1 protuberance within the ribosome.
+The line below this paragraph, {{ABSTRACT_PUBMED_12514741}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12514741 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12514741}}
 ==About this Structure==
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 [[Category: Ribosome]]
 [[Category: Rna-protein complex]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 01:54:32 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:30:39 2008''