4u8m: Difference between revisions
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== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/ | [https://www.uniprot.org/uniprot/GLFA_ASPFM GLFA_ASPFM] UDP-galactopyranose mutase, key flavoenzyme of galactofuranose metabolism that catalyzes the 6-to-5 ring contraction of UDP-galactopyranose to UDP-galactofuranose, the donor used by various galacto-furanosyltransferases (PubMed:16207086, PubMed:18552284, PubMed:22334662, PubMed:23036087, PubMed:25412209, PubMed:26836146). Controls the biosynthesis of galactomannan and galactofuranose containing glycoconjugates (PubMed:18552284). The flavin functions as nucleophile, forming a flavin-sugar adduct that facilitates galactose-ring opening and contraction (PubMed:26836146). The binding of UDP-galactopyranose induces profound conformational changes in the enzyme and two loops on opposite sides of the active site move toward each other by over 10 Angstroms to cover the substrate and create a closed active site (PubMed:22334662).<ref>PMID:16207086</ref> <ref>PMID:18552284</ref> <ref>PMID:22334662</ref> <ref>PMID:23036087</ref> <ref>PMID:25412209</ref> <ref>PMID:26836146</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
