1n3y: Difference between revisions

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[[Image:1n3y.jpg|left|200px]]
{{Seed}}
[[Image:1n3y.png|left|200px]]


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{{STRUCTURE_1n3y|  PDB=1n3y  |  SCENE=  }}  
{{STRUCTURE_1n3y|  PDB=1n3y  |  SCENE=  }}  


'''Crystal structure of the alpha-X beta2 integrin I domain'''
===Crystal structure of the alpha-X beta2 integrin I domain===




==Overview==
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The integrin alpha X beta 2 (CD11c/CD18, p150,95) binds ligands through the I domain of the alpha X subunit. Ligands include the complement factor fragment iC3b, a key component in the innate immune defense, which, together with the expression of alpha X beta 2 on dendritic cells and on other leukocytes, suggests a role in the immune response. We now report the structure of the alpha X I domain resolved at 1.65 A by x-ray crystallography. To analyze structural requirements for ligand binding we made a mutation in the alpha X I domain C-terminal helix, which increased the affinity for iC3b approximately 200-fold to 2.4 microM compared with the wild-type domain affinity of approximately 400 microM. Gel permeation chromatography supported a conformational change between the wild-type and mutated domains. Conservation of allosteric regulation in the alpha X I domain points to the functional importance of this phenomenon.
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{{ABSTRACT_PUBMED_12554829}}


==About this Structure==
==About this Structure==
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[[Category: Vorup-Jensen, T.]]
[[Category: Vorup-Jensen, T.]]
[[Category: Alpha/beta rossmann fold]]
[[Category: Alpha/beta rossmann fold]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 02:03:42 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:38:59 2008''

Revision as of 14:39, 27 July 2008

File:1n3y.png

Template:STRUCTURE 1n3y

Crystal structure of the alpha-X beta2 integrin I domain

Template:ABSTRACT PUBMED 12554829

About this Structure

1N3Y is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure and allosteric regulation of the alpha X beta 2 integrin I domain., Vorup-Jensen T, Ostermeier C, Shimaoka M, Hommel U, Springer TA, Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1873-8. Epub 2003 Jan 28. PMID:12554829

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