1n47: Difference between revisions

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[[Image:1n47.gif|left|200px]]
{{Seed}}
[[Image:1n47.png|left|200px]]


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{{STRUCTURE_1n47|  PDB=1n47  |  SCENE=  }}  
{{STRUCTURE_1n47|  PDB=1n47  |  SCENE=  }}  


'''Isolectin B4 from Vicia villosa in complex with the Tn antigen'''
===Isolectin B4 from Vicia villosa in complex with the Tn antigen===




==Overview==
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The structure of the tetrameric Vicia villosa isolectin B4 (VVLB4) in complex with a cancer antigen, the Tn glycopeptide (GalNAc-O-Ser), was determined at 2.7 A resolution. The N-acetylgalactoside moiety of the ligand binds to the primary combining site of VVLB4 in a similar way as observed for other Gal/GalNAc-specific plant lectins. The amino acid moiety of the Tn antigen is largely exposed to the solvent and makes few contacts with the protein. The structure of the complex provides a framework to understand the differences in the strength of VVLB4 binding to different sugars and emphasizes the role of a single protein residue, Tyr127, as a structural determinant of Tn-binding specificity.
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{{ABSTRACT_PUBMED_12586347}}


==About this Structure==
==About this Structure==
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[[Category: Glycoprotein tn-binding protein]]
[[Category: Glycoprotein tn-binding protein]]
[[Category: Vicia villosa lectin]]
[[Category: Vicia villosa lectin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:22:40 2008''
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