Theoretical models: Difference between revisions
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The success of structure prediction methods is assessed biannually in the ''Critical Assessment of techniques for protein Structure Prediction'' ([[CASP]]) competitions<ref>[http://predictioncenter.gc.ucdavis.edu/ Critical Assessment of techniques for protein Structure Prediction (CASP)].</ref>. Crystallographers submit sequences which they have solved, but for which the structures have not yet been published. Modelers predict the structures which are then compared with subsequently published structures. Beginning in CASP5 (2002), the ability to predict [[Intrinsically Disordered Protein|intrinsic disorder]] was included<ref>PMID: 19774619</ref>. Assessment of CASP results is done in a '''double-blind''' manner: the predictors do not have access to the empirical structures, and the assessors do not know the identities of the predictors, which are coded. | The success of structure prediction methods is assessed biannually in the ''Critical Assessment of techniques for protein Structure Prediction'' ([[CASP]]) competitions<ref>[http://predictioncenter.gc.ucdavis.edu/ Critical Assessment of techniques for protein Structure Prediction (CASP)].</ref>. Crystallographers submit sequences which they have solved, but for which the structures have not yet been published. Modelers predict the structures which are then compared with subsequently published structures. Beginning in CASP5 (2002), the ability to predict [[Intrinsically Disordered Protein|intrinsic disorder]] was included<ref>PMID: 19774619</ref>. Assessment of CASP results is done in a '''double-blind''' manner: the predictors do not have access to the empirical structures, and the assessors do not know the identities of the predictors, which are coded. | ||
There | There have also been competitions to predict protein-protein docking interactions<ref>[http://www.ebi.ac.uk/msd-srv/capri/ CAPRI: Critical Assessment of PRediction of Interactions].</ref> More recently, AlphaFold Multimer and AlphaFold 3 attempt to predict protein oligomers. | ||
===2022: CASP 15=== | ===2022: CASP 15=== | ||
