1n66: Difference between revisions

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[[Image:1n66.gif|left|200px]]
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[[Image:1n66.png|left|200px]]


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{{STRUCTURE_1n66|  PDB=1n66  |  SCENE=  }}  
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'''Structure of the pyrimidine-rich internal loop in the Y-domain of poliovirus 3'UTR'''
===Structure of the pyrimidine-rich internal loop in the Y-domain of poliovirus 3'UTR===




==Overview==
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Formation of non-canonical base-pairs in RNA often plays a very important functional role. In addition they frequently serve as factors in stabilizing the secondary structure elements that provide the frame of large compact RNA structures. Here we describe the structure of an internal loop containing a 5'CU3'/5'UU3' non-canonical tandem base-pair motif, which is conserved within the 3'-UTR of poliovirus-like enteroviruses. Structural details reveal striking regularities of the local helix geometry, resulting from alternating geometrical adjustments, which are important for understanding and predicting stabilities and configurations of tandem non-canonical base-pairs. The C-U and U-U base-pairs severely contract the minor groove of the sugar-phosphate backbone, which might be important for protein recognition or binding to other RNA elements.
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{{ABSTRACT_PUBMED_12909008}}


==About this Structure==
==About this Structure==
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N66 OCA].  
Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N66 OCA].  


==Reference==
==Reference==
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[[Category: Tessari, M.]]
[[Category: Tessari, M.]]
[[Category: Rna internal loop]]
[[Category: Rna internal loop]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 02:08:40 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:15:17 2008''

Revision as of 20:15, 27 July 2008

File:1n66.png

Template:STRUCTURE 1n66

Structure of the pyrimidine-rich internal loop in the Y-domain of poliovirus 3'UTR

Template:ABSTRACT PUBMED 12909008

About this Structure

Full experimental information is available from OCA.

Reference

Structure of the pyrimidine-rich internal loop in the poliovirus 3'-UTR: the importance of maintaining pseudo-2-fold symmetry in RNA helices containing two adjacent non-canonical base-pairs., Lescrinier EM, Tessari M, van Kuppeveld FJ, Melchers WJ, Hilbers CW, Heus HA, J Mol Biol. 2003 Aug 22;331(4):759-69. PMID:12909008

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