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| {{STRUCTURE_1n71| PDB=1n71 | SCENE= }} | | {{STRUCTURE_1n71| PDB=1n71 | SCENE= }} |
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| '''Crystal structure of aminoglycoside 6'-acetyltransferase type Ii in complex with coenzyme A'''
| | ===Crystal structure of aminoglycoside 6'-acetyltransferase type Ii in complex with coenzyme A=== |
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| ==Overview==
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| The rise of antibiotic resistance as a public health concern has led to increased interest in studying the ways in which bacteria avoid the effects of antibiotics. Enzymatic inactivation by several families of enzymes has been observed to be the predominant mechanism of resistance to aminoglycoside antibiotics such as kanamycin and gentamicin. Despite the importance of acetyltransferases in bacterial resistance to aminoglycoside antibiotics, relatively little is known about their structure and mechanism. Here we report the three-dimensional atomic structure of the aminoglycoside acetyltransferase AAC(6')-Ii in complex with coenzyme A (CoA). This structure unambiguously identifies the physiologically relevant AAC(6')-Ii dimer species, and reveals that the enzyme structure is similar in the AcCoA and CoA bound forms. AAC(6')-Ii is a member of the GCN5-related N-acetyltransferase (GNAT) superfamily of acetyltransferases, a diverse group of enzymes that possess a conserved structural motif, despite low sequence homology. AAC(6')-Ii is also a member of a subset of enzymes in the GNAT superfamily that form multimeric complexes. The dimer arrangements within the multimeric GNAT superfamily members are compared, revealing that AAC(6')-Ii forms a dimer assembly that is different from that observed in the other multimeric GNAT superfamily members. This different assembly may provide insight into the evolutionary processes governing dimer formation. | | The line below this paragraph, {{ABSTRACT_PUBMED_12592013}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 12592013 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_12592013}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Antibiotic resistance]] | | [[Category: Antibiotic resistance]] |
| [[Category: Coenzyme some]] | | [[Category: Coenzyme some]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:10:33 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:23:33 2008'' |
