1n7m: Difference between revisions

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[[Image:1n7m.gif|left|200px]]
{{Seed}}
[[Image:1n7m.png|left|200px]]


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{{STRUCTURE_1n7m|  PDB=1n7m  |  SCENE=  }}  
{{STRUCTURE_1n7m|  PDB=1n7m  |  SCENE=  }}  


'''Germline 7G12 with N-methylmesoporphyrin'''
===Germline 7G12 with N-methylmesoporphyrin===




==Overview==
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The crystal structure of the Michaelis complex between the Fab fragment of ferrochelatase antibody 7G12 and its substrate mesoporphyrin has been solved to 2.6-A resolution. The antibody-bound mesoporphyrin clearly adopts a nonplanar conformation and reveals that the antibody catalyzes the porphyrin metallation reaction by straining/distorting the bound substrate toward the transition-state configuration. The crystal structures of the Fab fragment of the germ-line precursor antibody to 7G12 and its complex with the hapten N-methylmesoporphyrin have also been solved. A comparison of these structures with the corresponding structures of the affinity-matured antibody 7G12 reveals the molecular mechanism by which the immune system evolves binding energy to catalyze this reaction.
The line below this paragraph, {{ABSTRACT_PUBMED_12552112}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 12552112 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12552112}}


==About this Structure==
==About this Structure==
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[[Category: Yin, J.]]
[[Category: Yin, J.]]
[[Category: Immune system]]
[[Category: Immune system]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 02:11:38 2008''
 
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