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| == Function == | | == Function == |
| [https://www.uniprot.org/uniprot/Q9KLD7_VIBCH Q9KLD7_VIBCH] | | [https://www.uniprot.org/uniprot/Q9KLD7_VIBCH Q9KLD7_VIBCH] |
| <div style="background-color:#fffaf0;">
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| == Publication Abstract from PubMed ==
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| Photolyases are flavoproteins, which are able to repair UV-induced DNA lesions in a light-dependant manner. According to their substrate, they can be distinguished as CPD- and (6-4) photolyases. While CPD-photolyases repair the predominantly occurring cyclobutane pyrimidine dimer lesion, (6-4) photolyases catalyse the repair of the less prominent (6-4) photoproduct. The subgroup of prokaryotic (6-4) photolyases/FeS-BCP is one of the most ancient types of flavoproteins in the ubiquitously occurring photolyase & cryptochrome superfamily (PCSf). In contrast to canonical photolyases, prokaryotic (6-4) photolyases possess a few particular characteristics, including a lumazine derivative as antenna chromophore beside the catalytically essential flavin adenine dinucleotide as well as an elongated linker region between the N-terminal alpha/beta-domain and the C-terminal all-alpha-helical domain. Furthermore, they can harbour an additional short subdomain, located at the C-terminus, with a binding site for a [4Fe-4S] cluster. So far two crystal structures of prokaryotic (6-4) photolyases have been reported. Within this study we present the high-resolution structure of the prokaryotic (6-4) photolyase from Vibrio cholerae and its spectroscopic characterization in terms of in vitro photoreduction and DNA-repair activity.
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| Structural and Functional Analysis of a Prokaryotic (6-4) Photolyase from the Aquatic Pathogen Vibrio Cholerae.,Emmerich HJ, Schneider L, Essen LO Photochem Photobiol. 2023 Jan 24. doi: 10.1111/php.13783. PMID:36692077<ref>PMID:36692077</ref>
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| From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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| </div>
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| <div class="pdbe-citations 8a1h" style="background-color:#fffaf0;"></div>
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| == References ==
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| <references/>
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| __TOC__ | | __TOC__ |
| </StructureSection> | | </StructureSection> |
