1nco: Difference between revisions

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[[Image:1nco.~~gif~~|left|200px]]

[[Image:1nco.png|left|200px]]

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~~'''~~STRUCTURE OF THE ANTITUMOR PROTEIN-CHROMOPHORE COMPLEX NEOCARZINOSTATIN~~'''~~

===STRUCTURE OF THE ANTITUMOR PROTEIN-CHROMOPHORE COMPLEX NEOCARZINOSTATIN===

~~==Overview==~~

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~~Structures of~~ the ~~protein-chromophore complex and~~ the ~~apoprotein form of neocarzinostatin were determined~~ at 1.~~8 angstrom resolution~~. ~~Neocarzinostatin~~ is ~~composed of a labile chromophore with DNA-cleaving activity and a stabilizing protein. The chromophore displays marked nonlinearity of~~ the ~~triple bonds and is bound noncovalently in a pocket formed by the two protein domains~~. ~~The chromophore pi~~-~~face interacts with the phenyl ring edges of Phe52 and Phe78. The amino sugar and carbonate groups of the chromophore are solvent exposed, whereas the epoxide, acetylene groups, and carbon C~~-12, the site of nucleophilic thiol addition during chromophore activation, are unexposed. The position of the amino group of the chromophore carbohydrate relative to C-12 supports the idea that the amino group plays a role in thiol activation.

The line below this paragraph, {{ABSTRACT_PUBMED_8235619}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 8235619 is the PubMed ID number.

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==About this Structure==

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[[Category: Rees, D C.]]

[[Category: Antibacterial and antitumor protein]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 02~~:22:27 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:23:11 2008''

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-[[Image:1nco.gif|left|200px]]
+{{Seed}}
+[[Image:1nco.png|left|200px]]
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 {{STRUCTURE_1nco|  PDB=1nco  |  SCENE=  }}
-'''STRUCTURE OF THE ANTITUMOR PROTEIN-CHROMOPHORE COMPLEX NEOCARZINOSTATIN'''
+===STRUCTURE OF THE ANTITUMOR PROTEIN-CHROMOPHORE COMPLEX NEOCARZINOSTATIN===
-==Overview==
+<!--
-Structures of the protein-chromophore complex and the apoprotein form of neocarzinostatin were determined at 1.8 angstrom resolution. Neocarzinostatin is composed of a labile chromophore with DNA-cleaving activity and a stabilizing protein. The chromophore displays marked nonlinearity of the triple bonds and is bound noncovalently in a pocket formed by the two protein domains. The chromophore pi-face interacts with the phenyl ring edges of Phe52 and Phe78. The amino sugar and carbonate groups of the chromophore are solvent exposed, whereas the epoxide, acetylene groups, and carbon C-12, the site of nucleophilic thiol addition during chromophore activation, are unexposed. The position of the amino group of the chromophore carbohydrate relative to C-12 supports the idea that the amino group plays a role in thiol activation.
+The line below this paragraph, {{ABSTRACT_PUBMED_8235619}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 8235619 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_8235619}}
 ==About this Structure==
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 [[Category: Rees, D C.]]
 [[Category: Antibacterial and antitumor protein]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 02:22:27 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:23:11 2008''