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| [[Image:1ncy.jpg|left|200px]] | | {{Seed}} |
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| {{STRUCTURE_1ncy| PDB=1ncy | SCENE= }} | | {{STRUCTURE_1ncy| PDB=1ncy | SCENE= }} |
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| '''TROPONIN-C, COMPLEX WITH MANGANESE'''
| | ===TROPONIN-C, COMPLEX WITH MANGANESE=== |
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| ==Overview==
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| The crystal structures of three metal complexes of troponin C (TnC) have been determined and refined where the two occupied structural Ca(2+) sites in the C domain have been substituted by Mn(2+), Cd(2+) and Tb(3+). The X-ray intensity data were collected to 2.1, 1.8 and 1.8 A resolution, respectively, on the three metal complexes, which are isomorphous with Ca-TnC. The three complexes have r.m.s. deviations of 0.27, 0.25 and 0.35 A, respectively, for all protein atoms, from Ca-TnC. Irrespective of the charge on the metal (+2 or +3), the occupied sites 3 and 4 exhibit a distorted pentagonal bipyramidal coordination, like Ca-TnC, with seven ligands, six from the 12-residue binding loop and the seventh from a water molecule. Mn(2+) at site 4 seems to display a longer distance to one of the carboxyl bidentate ligands representing an intermediate coordination simulating the six-coordinate Mg(2+). The carboxyl O atoms of the bidentate Glu12 are displaced on the side of the equatorial plane passing through the remaining three ligands with one O atom closer to the plane (Delta of 0.11 to 0.76 A) than the other (Delta of 0.93 to 1.38 A). The two axial ligands are an aspartic carboxyl O atom and a water molecule. The metal is displaced (0.18 to 0.56 A) towards the water facing the water channel.
| | The line below this paragraph, {{ABSTRACT_PUBMED_15299599}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 15299599 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_15299599}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Calcium-binding protein]] | | [[Category: Calcium-binding protein]] |
| [[Category: Muscle protein]] | | [[Category: Muscle protein]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:23:02 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:30:16 2008'' |
