1ne5: Difference between revisions

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[[Image:1ne5.jpg|left|200px]]
{{Seed}}
[[Image:1ne5.png|left|200px]]


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{{STRUCTURE_1ne5|  PDB=1ne5  |  SCENE=  }}  
{{STRUCTURE_1ne5|  PDB=1ne5  |  SCENE=  }}  


'''Solution Strucuture of HERG Specific Scorpion Toxin CnErg1'''
===Solution Strucuture of HERG Specific Scorpion Toxin CnErg1===




==Overview==
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The three-dimensional structure of chemically synthesized CnErg1 (Ergtoxin), which specifically blocks HERG (human ether-a-go-go-related gene) K+ channels, was determined by nuclear magnetic resonance spectroscopy. CnErg1 consists of a triple-stranded beta-sheet and an alpha-helix, as is typical of K+ channel scorpion toxins. The peptide structure differs from the canonical structures in that the first beta-strand is shorter and is nearer to the second beta-strand rather than to the third beta-strand on the C-terminus. There is also a large hydrophobic patch on the surface of the toxin, surrounding a central lysine residue, Lys13. We postulate that this hydrophobic patch is likely to form part of the binding surface of the toxin.
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{{ABSTRACT_PUBMED_12650941}}


==About this Structure==
==About this Structure==
1NE5 is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NE5 OCA].  
1NE5 is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NE5 OCA].  


==Reference==
==Reference==
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[[Category: Alpha-helix]]
[[Category: Alpha-helix]]
[[Category: Triple-stranded beta-sheet]]
[[Category: Triple-stranded beta-sheet]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 02:25:20 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:25:49 2008''

Revision as of 04:25, 29 July 2008

File:1ne5.png

Template:STRUCTURE 1ne5

Solution Strucuture of HERG Specific Scorpion Toxin CnErg1

Template:ABSTRACT PUBMED 12650941

About this Structure

1NE5 is a Single protein structure. Full experimental information is available from OCA.

Reference

Solution structure of CnErg1 (Ergtoxin), a HERG specific scorpion toxin., Torres AM, Bansal P, Alewood PF, Bursill JA, Kuchel PW, Vandenberg JI, FEBS Lett. 2003 Mar 27;539(1-3):138-42. PMID:12650941

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