6ukd: Difference between revisions

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<StructureSection load='6ukd' size='340' side='right'caption='[[6ukd]], [[Resolution|resolution]] 1.59&Aring;' scene=''>
<StructureSection load='6ukd' size='340' side='right'caption='[[6ukd]], [[Resolution|resolution]] 1.59&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6ukd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pyogenes_ATCC_10782 Streptococcus pyogenes ATCC 10782]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UKD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6UKD FirstGlance]. <br>
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UKD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6UKD FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.589&#8491;</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.589&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=Q9D:benzyl+[(2S)-1-(3-nitrophenyl)-3-oxobutan-2-yl]carbamate'>Q9D</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=Q9D:benzyl+[(2S)-1-(3-nitrophenyl)-3-oxobutan-2-yl]carbamate'>Q9D</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ukd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ukd OCA], [https://pdbe.org/6ukd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ukd RCSB], [https://www.ebi.ac.uk/pdbsum/6ukd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ukd ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ukd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ukd OCA], [https://pdbe.org/6ukd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ukd RCSB], [https://www.ebi.ac.uk/pdbsum/6ukd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ukd ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SPEB_STRPY SPEB_STRPY] Important streptococcal virulence factor which cleaves human fibronectin and degrades vitronectin. Also cleaves human IL1B precursor to form biologically active IL1B. Can induce apoptosis in human monocytes and epithelial cells in vitro, and reduces phagocytic activity in monocytic cells. Thus, may play a role in bacterial colonization, invasion, and inhibition of wound healing.<ref>PMID:9864206</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Streptococcus pyogenes ATCC 10782]]
[[Category: Kitamura S]]
[[Category: Kitamura S]]
[[Category: Woehl JL]]
[[Category: Woehl JL]]
[[Category: Wolan DW]]
[[Category: Wolan DW]]

Latest revision as of 05:51, 21 November 2024

Co-complex of S. pyogenes 10782 streptopain bound with a nitrile-based specific covalent inhibitor

6ukd, resolution 1.59Å

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