2h0x: Difference between revisions

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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2h0x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h0x OCA], [https://pdbe.org/2h0x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2h0x RCSB], [https://www.ebi.ac.uk/pdbsum/2h0x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2h0x ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2h0x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h0x OCA], [https://pdbe.org/2h0x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2h0x RCSB], [https://www.ebi.ac.uk/pdbsum/2h0x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2h0x ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The glmS ribozyme is the only natural catalytic RNA known to require a small-molecule activator for catalysis. This catalytic RNA functions as a riboswitch, with activator-dependent RNA cleavage regulating glmS messenger RNA expression. We report crystal structures of the glmS ribozyme in precleavage states that are unliganded or bound to the competitive inhibitor glucose-6-phosphate and in the postcleavage state. All structures superimpose closely, revealing a remarkably rigid RNA that contains a preformed active and coenzyme-binding site. Unlike other riboswitches, the glmS ribozyme binds its activator in an open, solvent-accessible pocket. Our structures suggest that the amine group of the glmS ribozyme-bound coenzyme performs general acid-base and electrostatic catalysis.
Structural basis of glmS ribozyme activation by glucosamine-6-phosphate.,Klein DJ, Ferre-D'Amare AR Science. 2006 Sep 22;313(5794):1752-6. PMID:16990543<ref>PMID:16990543</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2h0x" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Ribozyme 3D structures|Ribozyme 3D structures]]
*[[Ribozyme 3D structures|Ribozyme 3D structures]]
== References ==
<references/>
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