1njo: Difference between revisions

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[[Image:1njo.~~gif~~|left|200px]]

[[Image:1njo.png|left|200px]]

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~~'''~~The crystal structure of the 50S Large ribosomal subunit from Deinococcus radiodurans complexed with a short substrate analog ACCPuromycin (ACCP)~~'''~~

===The crystal structure of the 50S Large ribosomal subunit from Deinococcus radiodurans complexed with a short substrate analog ACCPuromycin (ACCP)===

~~==Overview==~~

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~~Crystal structures of tRNA mimics complexed with~~ the ~~large ribosomal subunit of Deinococcus radiodurans indicate that remote interactions determine~~ the ~~precise orientation of tRNA in the peptidyl-transferase center~~ (~~PTC)~~. ~~The PTC tolerates various orientations of puromycin derivatives and its flexibility allows the conformational rearrangements required for peptide-bond formation~~. ~~Sparsomycin binds to A2602 and alters the PTC conformation. H69~~, the ~~intersubunit-bridge connecting the PTC and decoding site, may also participate in tRNA placement and translocation~~. ~~A spiral rotation of the 3' end of the A~~-~~site tRNA around a 2~~-fold axis of symmetry identified within the PTC suggests a unified ribosomal machinery for peptide-bond formation, A-to-P-site translocation, and entrance of nascent proteins into the exit tunnel. Similar 2-fold related regions, detected in all known structures of large ribosomal subunits, indicate the universality of this mechanism.

The line below this paragraph, {{ABSTRACT_PUBMED_12535524}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 12535524 is the PubMed ID number.

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==About this Structure==

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[[Category: Sparsomycin]]

[[Category: Trna]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 02~~:36:48 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:08:14 2008''

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-[[Image:1njo.gif|left|200px]]
+{{Seed}}
+[[Image:1njo.png|left|200px]]
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 {{STRUCTURE_1njo|  PDB=1njo  |  SCENE=  }}
-'''The crystal structure of the 50S Large ribosomal subunit from Deinococcus radiodurans complexed with a short substrate analog ACCPuromycin (ACCP)'''
+===The crystal structure of the 50S Large ribosomal subunit from Deinococcus radiodurans complexed with a short substrate analog ACCPuromycin (ACCP)===
-==Overview==
+<!--
-Crystal structures of tRNA mimics complexed with the large ribosomal subunit of Deinococcus radiodurans indicate that remote interactions determine the precise orientation of tRNA in the peptidyl-transferase center (PTC). The PTC tolerates various orientations of puromycin derivatives and its flexibility allows the conformational rearrangements required for peptide-bond formation. Sparsomycin binds to A2602 and alters the PTC conformation. H69, the intersubunit-bridge connecting the PTC and decoding site, may also participate in tRNA placement and translocation. A spiral rotation of the 3' end of the A-site tRNA around a 2-fold axis of symmetry identified within the PTC suggests a unified ribosomal machinery for peptide-bond formation, A-to-P-site translocation, and entrance of nascent proteins into the exit tunnel. Similar 2-fold related regions, detected in all known structures of large ribosomal subunits, indicate the universality of this mechanism.
+The line below this paragraph, {{ABSTRACT_PUBMED_12535524}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12535524 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12535524}}
 ==About this Structure==
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 [[Category: Sparsomycin]]
 [[Category: Trna]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 02:36:48 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:08:14 2008''