7mc9: Difference between revisions

Latest revision as of 10:01, 25 December 2024

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 </table>
 == Function ==
-[https://www.uniprot.org/uniprot/A0A059VJE6_9ALPC A0A059VJE6_9ALPC] Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter.[ARBA:ARBA00002928]  Nsp9 is a ssRNA-binding protein.[ARBA:ARBA00003140]  The papain-like proteinase 1 (PLP1) and papain-like proteinase 2 (PLP2) are responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PLP2 possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. PLP2 also antagonizes innate immune induction of type I interferon by blocking the nuclear translocation of host IRF-3.[ARBA:ARBA00025562]
+[https://www.uniprot.org/uniprot/A0A059VJE6_9ALPC A0A059VJE6_9ALPC]
+==See Also==
+*[[3D structures of ubiquitin|3D structures of ubiquitin]]
 __TOC__
 </StructureSection>