1nn7: Difference between revisions

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~~'''~~Crystal Structure Of The Tetramerization Domain Of The Shal Voltage-Gated Potassium Channel~~'''~~

===Crystal Structure Of The Tetramerization Domain Of The Shal Voltage-Gated Potassium Channel===

~~==Overview==~~

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~~We have developed a semiempirical algorithm called Family Values (FamVal)~~, ~~which identifies residues that encode functional specificity in a protein sequence. Given a multiple sequence alignment (MSA) grouped into functionally distinct subfamilies~~, ~~FamVal calculates a specificity score for each subfamily at every amino acid position of an MSA. This algorithm was used~~ to ~~predict specificity-encoding positions within~~ the ~~tetramerization assembly~~ (~~T1) domain of voltage-gated potassium (Kv) channel subfamilies Kv3 and Kv4~~. ~~The importance of one such position (Arg to Ala at MSA position 93~~) ~~was confirmed by in vitro pull-down assays. The structural basis of this assembly discrimination was elucidated by determining~~ the ~~crystal structure of the Kv4 T1 domain and comparing it to the Kv3 T1 domain~~.

The line below this paragraph, {{ABSTRACT_PUBMED_12835418}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 12835418 is the PubMed ID number.

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==About this Structure==

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[[Category: Teteramerization domain]]

[[Category: Voltage gated potassium channel]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 02~~:44~~:21~~ 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:56:44 2008''

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-[[Image:1nn7.gif|left|200px]]
+{{Seed}}
+[[Image:1nn7.png|left|200px]]
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 {{STRUCTURE_1nn7|  PDB=1nn7  |  SCENE=  }}
-'''Crystal Structure Of The Tetramerization Domain Of The Shal Voltage-Gated Potassium Channel'''
+===Crystal Structure Of The Tetramerization Domain Of The Shal Voltage-Gated Potassium Channel===
-==Overview==
+<!--
-We have developed a semiempirical algorithm called Family Values (FamVal), which identifies residues that encode functional specificity in a protein sequence. Given a multiple sequence alignment (MSA) grouped into functionally distinct subfamilies, FamVal calculates a specificity score for each subfamily at every amino acid position of an MSA. This algorithm was used to predict specificity-encoding positions within the tetramerization assembly (T1) domain of voltage-gated potassium (Kv) channel subfamilies Kv3 and Kv4. The importance of one such position (Arg to Ala at MSA position 93) was confirmed by in vitro pull-down assays. The structural basis of this assembly discrimination was elucidated by determining the crystal structure of the Kv4 T1 domain and comparing it to the Kv3 T1 domain.
+The line below this paragraph, {{ABSTRACT_PUBMED_12835418}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12835418 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12835418}}
 ==About this Structure==
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 [[Category: Teteramerization domain]]
 [[Category: Voltage gated potassium channel]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 02:44:21 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:56:44 2008''