1nor: Difference between revisions

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[[Image:1nor.gif|left|200px]]
{{Seed}}
[[Image:1nor.png|left|200px]]


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{{STRUCTURE_1nor|  PDB=1nor  |  SCENE=  }}  
{{STRUCTURE_1nor|  PDB=1nor  |  SCENE=  }}  


'''TWO-DIMENSIONAL 1H-NMR STUDY OF THE SPATIAL STRUCTURE OF NEUROTOXIN II FROM NAJA OXIANA'''
===TWO-DIMENSIONAL 1H-NMR STUDY OF THE SPATIAL STRUCTURE OF NEUROTOXIN II FROM NAJA OXIANA===




==Overview==
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The spatial structure of neurotoxin II from the venom of the central Asian cobra Naja naja oxiana was determined by two-dimensional 1H-NMR techniques and computational analysis. Nearly complete proton resonance assignments for 61 amino acid residues have been made using two-dimensional (2D) homonuclear total correlated spectroscopy, 2D homonuclear double-quantum-filtered correlated spectroscopy and 2D homonuclear NOE spectroscopy (NOESY) experiments. The cross-peak volumes in NOESY spectra spin-spin coupling constants of vicinal protons NH-C alpha H and C alpha H-C beta H and the observation of slow deuterium exchange of amide protons were used to define local structure and a set of constraints for distance geometry program DIANA. The average root-mean-square deviations are 53 pm for backbone heavy atoms and 118 pm for all heavy atoms of 19 final neurotoxin II conformations. The spatial structure is characterized by a short double-stranded (residues 1-5 and 13-17) and a triple-stranded (residues 22-30, 33-41 and 50-54) antiparallel beta-sheets.
The line below this paragraph, {{ABSTRACT_PUBMED_8504813}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_8504813}}


==About this Structure==
==About this Structure==
1NOR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Naja_oxiana Naja oxiana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NOR OCA].  
1NOR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Naja_oxiana Naja oxiana]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NOR OCA].  


==Reference==
==Reference==
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[[Category: Utkin, Y N.]]
[[Category: Utkin, Y N.]]
[[Category: Neurotoxin]]
[[Category: Neurotoxin]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 02:47:29 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:22:25 2008''

Revision as of 23:22, 27 July 2008

File:1nor.png


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1nor, 19 NMR models (default scene)
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



TWO-DIMENSIONAL 1H-NMR STUDY OF THE SPATIAL STRUCTURE OF NEUROTOXIN II FROM NAJA OXIANA

Template:ABSTRACT PUBMED 8504813

About this Structure

1NOR is a Single protein structure of sequence from Naja oxiana. Full experimental information is available from OCA.

Reference

Two-dimensional 1H-NMR study of the spatial structure of neurotoxin II from Naja naja oxiana., Golovanov AP, Lomize AL, Arseniev AS, Utkin YN, Tsetlin VI, Eur J Biochem. 1993 May 1;213(3):1213-23. PMID:8504813

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