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| {{STRUCTURE_1not| PDB=1not | SCENE= }} | | {{STRUCTURE_1not| PDB=1not | SCENE= }} |
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| '''THE 1.2 ANGSTROM STRUCTURE OF G1 ALPHA CONOTOXIN'''
| | ===THE 1.2 ANGSTROM STRUCTURE OF G1 ALPHA CONOTOXIN=== |
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| ==Overview==
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| Predatory marine snails of the genus Conus paralyze their fish prey by injecting a potent toxin. The alpha-conotoxin GI is a 13-residue peptide isolated from venom of Conus geographus. It functions by blocking the postsynaptic nicotinic acetylcholine receptor. After crystallization in deionized water, the three-dimensional structure of the GI neurotoxin was determined to 1.2 A resolution by X-ray crystallography. This structure, which can be described as a triangular slab, shows overall similarities to those derived by NMR, CD, and predictive methods. The principal framework of the molecule is provided by two disulfide bonds, one linking Cys 2 and Cys 7 and the other Cys 3 and Cys 13. Opposite ends of the sequence are drawn together even further by hydrogen bonds between Glu 1 and Cys 13 and between Cys 2 and Ser 12. Since the C-terminus is amidated, only one negative charge is present (carboxylate of Glu 1), and this is not implicated in receptor binding. Two positively charged regions (the alpha-amino group of Glu 1 and the guanido group of Arg 9) are situated 15 A apart at the corners of the triangular face of the molecule. phi, psi angles characteristic of a 3(10) helix were observed for residues 5-7. For residues 8-11, these angles were consistent with either a type I beta-turn or a distorted 3(10) helix.
| | The line below this paragraph, {{ABSTRACT_PUBMED_8784187}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 8784187 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_8784187}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Disulphide loop]] | | [[Category: Disulphide loop]] |
| [[Category: Venom]] | | [[Category: Venom]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:47:41 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:20:55 2008'' |
