1nt0: Difference between revisions

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[[Image:1nt0.gif|left|200px]]
{{Seed}}
[[Image:1nt0.png|left|200px]]


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{{STRUCTURE_1nt0|  PDB=1nt0  |  SCENE=  }}  
{{STRUCTURE_1nt0|  PDB=1nt0  |  SCENE=  }}  


'''Crystal structure of the CUB1-EGF-CUB2 region of MASP2'''
===Crystal structure of the CUB1-EGF-CUB2 region of MASP2===




==Overview==
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Serum mannose-binding proteins (MBPs) are C-type lectins that recognize cell surface carbohydrate structures on pathogens, and trigger killing of these targets by activating the complement pathway. MBPs circulate as a complex with MBP-associated serine proteases (MASPs), which become activated upon engagement of a target cell surface. The minimal functional unit for complement activation is a MASP homodimer bound to two MBP trimeric subunits. MASPs have a modular structure consisting of an N-terminal CUB domain, a Ca(2+)-binding EGF-like domain, a second CUB domain, two complement control protein modules and a C-terminal serine protease domain. The CUB1-EGF-CUB2 region mediates homodimerization and binding to MBP. The crystal structure of the MASP-2 CUB1-EGF-CUB2 dimer reveals an elongated structure with a prominent concave surface that is proposed to be the MBP-binding site. A model of the full six-domain structure and its interaction with MBPs suggests mechanisms by which binding to a target cell transmits conformational changes from MBP to MASP that allow activation of its protease activity.
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{{ABSTRACT_PUBMED_12743029}}


==About this Structure==
==About this Structure==
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[[Category: Mannose-binding protein]]
[[Category: Mannose-binding protein]]
[[Category: Masp]]
[[Category: Masp]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 02:56:35 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:59:22 2008''

Revision as of 03:59, 29 July 2008

File:1nt0.png

Template:STRUCTURE 1nt0

Crystal structure of the CUB1-EGF-CUB2 region of MASP2

Template:ABSTRACT PUBMED 12743029

About this Structure

1NT0 is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the CUB1-EGF-CUB2 region of mannose-binding protein associated serine protease-2., Feinberg H, Uitdehaag JC, Davies JM, Wallis R, Drickamer K, Weis WI, EMBO J. 2003 May 15;22(10):2348-59. PMID:12743029

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