8wx2: Difference between revisions
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==Cryo-EM structure of human SLC15A3 (outward-facing partially occluded)== | |||
<StructureSection load='8wx2' size='340' side='right'caption='[[8wx2]], [[Resolution|resolution]] 3.44Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8wx2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8WX2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8WX2 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.44Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8wx2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8wx2 OCA], [https://pdbe.org/8wx2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8wx2 RCSB], [https://www.ebi.ac.uk/pdbsum/8wx2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8wx2 ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/S15A3_HUMAN S15A3_HUMAN] Proton-coupled amino-acid transporter that transports free histidine and certain di- and tripeptides, and is involved in innate immune response (By similarity). Also able to transport carnosine (PubMed:31073693, PubMed:31254495). Involved in the detection of microbial pathogens by toll-like receptors (TLRs) and NOD-like receptors (NLRs), probably by mediating transport of bacterial peptidoglycans across the endolysosomal membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand (By similarity).[UniProtKB:Q8BPX9]<ref>PMID:31073693</ref> <ref>PMID:31254495</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Kasai S]] | |||
[[Category: Ohto U]] | |||
[[Category: Shimizu T]] | |||
[[Category: Zhang Z]] | |||
Revision as of 08:08, 6 December 2023
Cryo-EM structure of human SLC15A3 (outward-facing partially occluded)
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