1nvt: Difference between revisions

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[[Image:1nvt.gif|left|200px]]
{{Seed}}
[[Image:1nvt.png|left|200px]]


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{{STRUCTURE_1nvt|  PDB=1nvt  |  SCENE=  }}  
{{STRUCTURE_1nvt|  PDB=1nvt  |  SCENE=  }}  


'''Crystal structure of Shikimate Dehydrogenase (AROE or MJ1084) in complex with NADP+'''
===Crystal structure of Shikimate Dehydrogenase (AROE or MJ1084) in complex with NADP+===




==Overview==
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The crystal structure of Methanococcus jannaschii shikimate 5-dehydrogenase (MjSDH) bound to the cofactor nicotinamide adenine dinucleotide phosphate (NADP) has been determined at 2.35 A resolution. Shikimate 5-dehydrogenase (SDH) is responsible for NADP-dependent catalysis of the fourth step in shikimate biosynthesis, which is essential for aromatic amino acid metabolism in bacteria, microbial eukaryotes, and plants. The structure of MjSDH is a compact alpha/beta sandwich with two distinct domains, responsible for binding substrate and the NADP cofactor, respectively. A phylogenetically conserved deep cleft on the protein surface corresponds to the enzyme active site. The structure reveals a topologically new domain fold within the N-terminal segment of the polypeptide chain, which binds substrate and supports dimerization. Insights gained from homology modeling and sequence/structure comparisons suggest that the SDHs represent a unique class of dehydrogenases. The structure provides a framework for further investigation to discover and develop novel inhibitors targeting this essential enzyme.
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{{ABSTRACT_PUBMED_12906831}}


==About this Structure==
==About this Structure==
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[[Category: Psi]]
[[Category: Psi]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 03:02:27 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:14:28 2008''

Revision as of 16:14, 28 July 2008

File:1nvt.png

Template:STRUCTURE 1nvt

Crystal structure of Shikimate Dehydrogenase (AROE or MJ1084) in complex with NADP+

Template:ABSTRACT PUBMED 12906831

About this Structure

1NVT is a Single protein structure of sequence from Methanocaldococcus jannaschii. Full crystallographic information is available from OCA.

Reference

Crystal structure of shikimate 5-dehydrogenase (SDH) bound to NADP: insights into function and evolution., Padyana AK, Burley SK, Structure. 2003 Aug;11(8):1005-13. PMID:12906831

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