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| [[Image:1ny7.gif|left|200px]] | | {{Seed}} |
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| {{STRUCTURE_1ny7| PDB=1ny7 | SCENE= }} | | {{STRUCTURE_1ny7| PDB=1ny7 | SCENE= }} |
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| '''COWPEA MOSAIC VIRUS (CPMV)'''
| | ===COWPEA MOSAIC VIRUS (CPMV)=== |
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| ==Overview==
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| Comoviruses are a group of plant viruses in the picornavirus superfamily. The type member of comoviruses, cowpea mosaic virus (CPMV), was crystallized in the cubic space group I23, a = 317 A and the hexagonal space group P6(1)22, a = 451 A, c = 1038 A. Structures of three closely similar nucleoprotein particles were determined in the cubic form. The roughly 300-A capsid was similar to the picornavirus capsid displaying a pseudo T = 3 (P = 3) surface lattice. The three beta-sandwich domains adopt two orientations, one with the long axis radial and the other two with the long axes tangential in reference to the capsid sphere. T = 3 viruses display one or the other of these two orientations. The CPMV capsid was permeable to cesium ions, leading to a disturbance of the beta-annulus inside a channel-like structure, suggesting an ion channel. The hexagonal crystal form diffracted X rays to 3 A resolution, despite the large unit cell. The large ( approximately 200 A) solvent channels in the lattice allow exchange of CPMV cognate Fab fragments. As an initial step in the structure determination of the CPMV/Fab complex, the P6(1)22 crystal structure was solved by molecular replacement with the CPMV model determined in the cubic cell.
| | The line below this paragraph, {{ABSTRACT_PUBMED_10603314}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 10603314 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_10603314}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Icosahedral virus]] | | [[Category: Icosahedral virus]] |
| [[Category: Virus]] | | [[Category: Virus]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:07:31 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:11:58 2008'' |
