1nyd: Difference between revisions

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[[Image:1nyd.~~gif~~|left|200px]]

[[Image:1nyd.png|left|200px]]

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~~'''~~Solution structure of DNA quadruplex GCGGTGGAT~~'''~~

===Solution structure of DNA quadruplex GCGGTGGAT===

~~==Overview==~~

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The ~~structure formed by~~ the ~~DNA sequence d~~(~~GCGGTGGAT) in a 100 mM Na(+) solution has been determined using molecular dynamics calculations constrained by distance and dihedral restraints derived from NMR experiments performed~~ at ~~isotopic natural abundance. The sequence folds into a dimer of dimers. Each symmetry-related half contains two parallel stranded G:G:G:G tetrads flanked by an A:A mismatch and by four-stranded G:C:G~~:~~C tetrads~~. ~~Each of the two juxtaposed G:C:G:C tetrads is composed of alternating antiparallel strands from the two halves of the dimer~~. ~~For each single strand~~, ~~a thymine intersperses a double chain reversal connecting~~ the juxtaposed G:G:G:G tetrads. This architecture has potential implications in genetic recombination. It suggests a pathway for oligomerization involving association of quadruplex entities through GpC steps.

The line below this paragraph, {{ABSTRACT_PUBMED_14661946}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 14661946 is the PubMed ID number.

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==About this Structure==

Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NYD OCA].

Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NYD OCA].

==Reference==

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[[Category: Parallel quadruplex]]

[[Category: Quadruplex]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 03~~:08:04 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:27:51 2008''

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-[[Image:1nyd.gif|left|200px]]
+{{Seed}}
+[[Image:1nyd.png|left|200px]]
 <!--
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 {{STRUCTURE_1nyd|  PDB=1nyd  |  SCENE=  }}
-'''Solution structure of DNA quadruplex GCGGTGGAT'''
+===Solution structure of DNA quadruplex GCGGTGGAT===
-==Overview==
+<!--
-The structure formed by the DNA sequence d(GCGGTGGAT) in a 100 mM Na(+) solution has been determined using molecular dynamics calculations constrained by distance and dihedral restraints derived from NMR experiments performed at isotopic natural abundance. The sequence folds into a dimer of dimers. Each symmetry-related half contains two parallel stranded G:G:G:G tetrads flanked by an A:A mismatch and by four-stranded G:C:G:C tetrads. Each of the two juxtaposed G:C:G:C tetrads is composed of alternating antiparallel strands from the two halves of the dimer. For each single strand, a thymine intersperses a double chain reversal connecting the juxtaposed G:G:G:G tetrads. This architecture has potential implications in genetic recombination. It suggests a pathway for oligomerization involving association of quadruplex entities through GpC steps.
+The line below this paragraph, {{ABSTRACT_PUBMED_14661946}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 14661946 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_14661946}}
 ==About this Structure==
-Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NYD OCA].
+Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NYD OCA].
 ==Reference==
@@ Line 25: / Line 29: @@
 [[Category: Parallel quadruplex]]
 [[Category: Quadruplex]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 03:08:04 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:27:51 2008''