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| {{STRUCTURE_1nyu| PDB=1nyu | SCENE= }} | | {{STRUCTURE_1nyu| PDB=1nyu | SCENE= }} |
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| '''Crystal Structure of Activin A Bound to the ECD of ActRIIB'''
| | ===Crystal Structure of Activin A Bound to the ECD of ActRIIB=== |
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| ==Overview==
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| The TGF-beta superfamily of ligands and receptors stimulate cellular events in diverse processes ranging from cell fate specification in development to immune suppression. Activins define a major subgroup of TGF-beta ligands that regulate cellular differentiation, proliferation, activation and apoptosis. Activins signal through complexes formed with type I and type II serine/threonine kinase receptors. We have solved the crystal structure of activin A bound to the extracellular domain of a type II receptor, ActRIIB, revealing the details of this interaction. ActRIIB binds to the outer edges of the activin finger regions, with the two receptors juxtaposed in close proximity, in a mode that differs from TGF-beta3 binding to type II receptors. The dimeric activin A structure differs from other known TGF-beta ligand structures, adopting a compact folded-back conformation. The crystal structure of the complex is consistent with recruitment of two type I receptors into a close packed arrangement at the cell surface and suggests that diversity in the conformational arrangements of TGF-beta ligand dimers could influence cellular signaling processes. | | The line below this paragraph, {{ABSTRACT_PUBMED_12660162}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 12660162 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_12660162}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Tgf beta]] | | [[Category: Tgf beta]] |
| [[Category: Type ii]] | | [[Category: Type ii]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:09:11 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:44:28 2008'' |
