1nz6: Difference between revisions

Line 1:

[[Image:1nz6.~~jpg~~|left|200px]]

[[Image:1nz6.png|left|200px]]

<!--

Line 9:

Line 10:

~~'''~~Crystal Structure of Auxilin J-Domain~~'''~~

===Crystal Structure of Auxilin J-Domain===

~~==Overview==~~

<!--

J-~~domains are widespread protein interaction modules involved in recruiting and stimulating the activity of Hsp70 family chaperones. We have determined the crystal structure of the J~~-~~domain of auxilin~~, ~~a protein which is involved in uncoating clathrin-coated vesicles. Comparison~~ to the ~~known structures of J-domains from four other proteins reveals that the auxilin J-domain~~ is the ~~most divergent of all J-domain structures described to date~~. ~~In addition to the canonical J~~-~~domain features described previously, the auxilin J~~-domain contains an extra N-terminal helix and a long loop inserted between helices I and II. The latter loop extends the positively charged surface which forms the Hsc70 binding site, and is shown by directed mutagenesis and surface plasmon resonance to contain side chains important for binding to Hsc70.

The line below this paragraph, {{ABSTRACT_PUBMED_12741832}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 12741832 is the PubMed ID number.

-->

==About this Structure==

Line 31:

Line 35:

[[Category: Alpha helix]]

[[Category: Anti-parallel helix hairpin]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 03~~:09:55 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:13:33 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:1nz6.jpg|left|200px]]
+{{Seed}}
+[[Image:1nz6.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1nz6|  PDB=1nz6  |  SCENE=  }}
-'''Crystal Structure of Auxilin J-Domain'''
+===Crystal Structure of Auxilin J-Domain===
-==Overview==
+<!--
-J-domains are widespread protein interaction modules involved in recruiting and stimulating the activity of Hsp70 family chaperones. We have determined the crystal structure of the J-domain of auxilin, a protein which is involved in uncoating clathrin-coated vesicles. Comparison to the known structures of J-domains from four other proteins reveals that the auxilin J-domain is the most divergent of all J-domain structures described to date. In addition to the canonical J-domain features described previously, the auxilin J-domain contains an extra N-terminal helix and a long loop inserted between helices I and II. The latter loop extends the positively charged surface which forms the Hsc70 binding site, and is shown by directed mutagenesis and surface plasmon resonance to contain side chains important for binding to Hsc70.
+The line below this paragraph, {{ABSTRACT_PUBMED_12741832}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12741832 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12741832}}
 ==About this Structure==
@@ Line 31: / Line 35: @@
 [[Category: Alpha helix]]
 [[Category: Anti-parallel helix hairpin]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 03:09:55 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:13:33 2008''