1o0k: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
Line 1: Line 1:
[[Image:1o0k.gif|left|200px]]
{{Seed}}
[[Image:1o0k.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1o0k|  PDB=1o0k  |  SCENE=  }}  
{{STRUCTURE_1o0k|  PDB=1o0k  |  SCENE=  }}  


'''Structure of the First Parallel DNA Quadruplex-drug Complex'''
===Structure of the First Parallel DNA Quadruplex-drug Complex===




==Overview==
<!--
The first crystal structure of a drug (daunomycin) bound to a parallel-stranded intermolecular telomeric G4 quadruplex (d(TGGGGT)4) has been determined to high resolution. A planar assemblage of three daunomycin molecules stacks onto the 5' end of the G4 column, with the daunosamine substituents occupying three of the four quadruplex grooves. The surface area of the terminal G-quartet in this parallel DNA quadruplex, presently occupied by three daunomycins, is sufficiently large that it could easily accommodate other potential telomerase inhibitors such as substituted porphyrins or telomestatin.
The line below this paragraph, {{ABSTRACT_PUBMED_12670225}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 12670225 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_12670225}}


==About this Structure==
==About this Structure==
Line 26: Line 30:
[[Category: G-4 quadruplex drug complex]]
[[Category: G-4 quadruplex drug complex]]
[[Category: Parallel quadruplex]]
[[Category: Parallel quadruplex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 03:12:46 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:28:01 2008''
Retrieved from "https://proteopedia.org/1o0k"