1o0p: Difference between revisions

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[[Image:1o0p.jpg|left|200px]]
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[[Image:1o0p.png|left|200px]]


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{{STRUCTURE_1o0p|  PDB=1o0p  |  SCENE=  }}  
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'''Solution Structure of the third RNA Recognition Motif (RRM) of U2AF65 in complex with an N-terminal SF1 peptide'''
===Solution Structure of the third RNA Recognition Motif (RRM) of U2AF65 in complex with an N-terminal SF1 peptide===




==Overview==
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The essential splicing factors SF1 and U2AF play an important role in the recognition of the pre-mRNA 3' splice site during early spliceosome assembly. The structure of the C-terminal RRM (RRM3) of human U2AF(65) complexed to an N-terminal peptide of SF1 reveals an extended negatively charged helix A and an additional helix C. Helix C shields the potential RNA binding surface. SF1 binds to the opposite, helical face of RRM3. It inserts a conserved tryptophan into a hydrophobic pocket between helices A and B in a way that strikingly resembles part of the molecular interface in the U2AF heterodimer. This molecular recognition establishes a paradigm for protein binding by a subfamily of noncanonical RRMs.
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{{ABSTRACT_PUBMED_12718882}}


==About this Structure==
==About this Structure==
1O0P is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O0P OCA].  
1O0P is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O0P OCA].  


==Reference==
==Reference==
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[[Category: 4-stranded anti-parallel beta-sheet]]
[[Category: 4-stranded anti-parallel beta-sheet]]
[[Category: Non-canonical rna recognition motif]]
[[Category: Non-canonical rna recognition motif]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 03:13:02 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:52:42 2008''

Revision as of 18:52, 28 July 2008

File:1o0p.png

Template:STRUCTURE 1o0p

Solution Structure of the third RNA Recognition Motif (RRM) of U2AF65 in complex with an N-terminal SF1 peptide

Template:ABSTRACT PUBMED 12718882

About this Structure

1O0P is a Protein complex structure of sequences from Homo sapiens. Full experimental information is available from OCA.

Reference

Structural basis for the molecular recognition between human splicing factors U2AF65 and SF1/mBBP., Selenko P, Gregorovic G, Sprangers R, Stier G, Rhani Z, Kramer A, Sattler M, Mol Cell. 2003 Apr;11(4):965-76. PMID:12718882

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