8qxp: Difference between revisions
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==Crystal structure of the outer membrane porin OmpW from Klebsiella pneumoniae== | |||
<StructureSection load='8qxp' size='340' side='right'caption='[[8qxp]], [[Resolution|resolution]] 3.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8qxp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8QXP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8QXP FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8qxp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8qxp OCA], [https://pdbe.org/8qxp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8qxp RCSB], [https://www.ebi.ac.uk/pdbsum/8qxp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8qxp ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/W9B759_KLEPN W9B759_KLEPN] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Conjugation is the process by which plasmids, including those that carry antibiotic-resistance genes, are mobilized from one bacterium (the donor) to another (the recipient). The conjugation efficiency of IncF-like plasmids relies on the formation of mating-pair stabilization via intimate interactions between outer membrane proteins on the donor (a plasmid-encoded TraN isoform) and recipient bacteria. Conjugation of the R100-1 plasmid into Escherichia coli and Klebsiella pneumoniae (KP) recipients relies on pairing between the plasmid-encoded TraNalpha in the donor and OmpW in the recipient. Here, the crystal structure of K. pneumoniae OmpW (OmpW(KP)) is reported at 3.2 A resolution. OmpW(KP) forms an eight-stranded beta-barrel flanked by extracellular loops. The structures of E. coli OmpW (OmpW(EC)) and OmpW(KP) show high conservation despite sequence variability in the extracellular loops. | |||
Structure of the outer membrane porin OmpW from the pervasive pathogen Klebsiella pneumoniae.,Seddon C, Frankel G, Beis K Acta Crystallogr F Struct Biol Commun. 2024 Jan 1;80(Pt 1):22-27. doi: , 10.1107/S2053230X23010579. Epub 2024 Jan 1. PMID:38206593<ref>PMID:38206593</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: | <div class="pdbe-citations 8qxp" style="background-color:#fffaf0;"></div> | ||
[[Category: | == References == | ||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Klebsiella pneumoniae]] | |||
[[Category: Large Structures]] | |||
[[Category: Beis K]] | |||
[[Category: Seddon C]] | |||
Latest revision as of 11:29, 24 January 2024
Crystal structure of the outer membrane porin OmpW from Klebsiella pneumoniae
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