1p8x: Difference between revisions

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[[Image:1p8x.gif|left|200px]]<br />

[[Image:1p8x.gif|left|200px]]<br /><applet load="1p8x" size="350" color="white" frame="true" align="right" spinBox="true"

<applet load="1p8x" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

caption="1p8x, resolution 2.0Å" />

'''The Calcium-Activated C-terminal half of gelsolin'''<br />

==Overview==

Gelsolin requires activation to carry out its severing and capping, activities on F-actin. Here, we present the structure of the isolated, C-terminal half of gelsolin (G4-G6) at 2.0 A resolution in the presence of, Ca(2+) ions. This structure completes a triptych of the states of, activation of G4-G6 that illuminates its role in the function of gelsolin., Activated G4-G6 displays an open conformation, with the actin-binding site, on G4 fully exposed and all three type-2 Ca(2+) sites occupied. Neither, actin nor the type-l Ca(2+), which normally is sandwiched between actin, and G4, is required to achieve this conformation.

Gelsolin requires activation to carry out its severing and capping activities on F-actin. Here, we present the structure of the isolated C-terminal half of gelsolin (G4-G6) at 2.0 A resolution in the presence of Ca(2+) ions. This structure completes a triptych of the states of activation of G4-G6 that illuminates its role in the function of gelsolin. Activated G4-G6 displays an open conformation, with the actin-binding site on G4 fully exposed and all three type-2 Ca(2+) sites occupied. Neither actin nor the type-l Ca(2+), which normally is sandwiched between actin and G4, is required to achieve this conformation.

==Disease==

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==About this Structure==

1P8X is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1P8X OCA].

1P8X is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P8X OCA].

==Reference==

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[[Category: Homo sapiens]]

[[Category: Single protein]]

[[Category: Burtnick, L.D.]]

[[Category: Burtnick, L D.]]

[[Category: Narayan, K.]]

[[Category: Robinson, R.C.]]

[[Category: Robinson, R C.]]

[[Category: CA]]

[[Category: calcium-binding]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Mon Nov 12 18~~:41:~~03 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:26:24 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1p8x.gif|left|200px]]<br />
+[[Image:1p8x.gif|left|200px]]<br /><applet load="1p8x" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="1p8x" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="1p8x, resolution 2.0&Aring;" />
 '''The Calcium-Activated C-terminal half of gelsolin'''<br />
 ==Overview==
-Gelsolin requires activation to carry out its severing and capping, activities on F-actin. Here, we present the structure of the isolated, C-terminal half of gelsolin (G4-G6) at 2.0 A resolution in the presence of, Ca(2+) ions. This structure completes a triptych of the states of, activation of G4-G6 that illuminates its role in the function of gelsolin., Activated G4-G6 displays an open conformation, with the actin-binding site, on G4 fully exposed and all three type-2 Ca(2+) sites occupied. Neither, actin nor the type-l Ca(2+), which normally is sandwiched between actin, and G4, is required to achieve this conformation.
+Gelsolin requires activation to carry out its severing and capping activities on F-actin. Here, we present the structure of the isolated C-terminal half of gelsolin (G4-G6) at 2.0 A resolution in the presence of Ca(2+) ions. This structure completes a triptych of the states of activation of G4-G6 that illuminates its role in the function of gelsolin. Activated G4-G6 displays an open conformation, with the actin-binding site on G4 fully exposed and all three type-2 Ca(2+) sites occupied. Neither actin nor the type-l Ca(2+), which normally is sandwiched between actin and G4, is required to achieve this conformation.
 ==Disease==
@@ Line 11: / Line 10: @@
 ==About this Structure==
-P8X is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1P8X OCA].
+P8X is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P8X OCA].
 ==Reference==
@@ Line 17: / Line 16: @@
 [[Category: Homo sapiens]]
 [[Category: Single protein]]
-[[Category: Burtnick, L.D.]]
+[[Category: Burtnick, L D.]]
 [[Category: Narayan, K.]]
-[[Category: Robinson, R.C.]]
+[[Category: Robinson, R C.]]
 [[Category: CA]]
 [[Category: calcium-binding]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 18:41:03 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:26:24 2008''