1o7z: Difference between revisions

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[[Image:1o7z.jpg|left|200px]]
{{Seed}}
[[Image:1o7z.png|left|200px]]


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{{STRUCTURE_1o7z|  PDB=1o7z  |  SCENE=  }}  
{{STRUCTURE_1o7z|  PDB=1o7z  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF IP-10 T-FORM'''
===CRYSTAL STRUCTURE OF IP-10 T-FORM===




==Overview==
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We have determined the structure of wild-type IP-10 from three crystal forms. The crystals provide eight separate models of the IP-10 chain, all differing substantially from a monomeric IP-10 variant examined previously by NMR spectroscopy. In each crystal form, IP-10 chains form conventional beta sheet dimers, which, in turn, form a distinct tetrameric assembly. The M form tetramer is reminiscent of platelet factor 4, whereas the T and H forms feature a novel twelve-stranded beta sheet. Analytical ultracentrifugation indicates that, in free solution, IP-10 exists in a monomer-dimer equilibrium with a dissociation constant of 9 microM. We propose that the tetrameric structures may represent species promoted by the binding of glycosaminoglycans. The binding sites for several IP-10-neutralizing mAbs have also been mapped.
The line below this paragraph, {{ABSTRACT_PUBMED_12737818}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_12737818}}


==About this Structure==
==About this Structure==
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[[Category: Swaminathan, G J.]]
[[Category: Swaminathan, G J.]]
[[Category: Chemokine,interferon induction,chemotaxis,inflammatory response]]
[[Category: Chemokine,interferon induction,chemotaxis,inflammatory response]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 03:30:07 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:18:49 2008''

Revision as of 02:18, 28 July 2008

File:1o7z.png

Template:STRUCTURE 1o7z

CRYSTAL STRUCTURE OF IP-10 T-FORM

Template:ABSTRACT PUBMED 12737818

About this Structure

1O7Z is a Single protein structure. Full crystallographic information is available from OCA.

Reference

Crystal structures of oligomeric forms of the IP-10/CXCL10 chemokine., Swaminathan GJ, Holloway DE, Colvin RA, Campanella GK, Papageorgiou AC, Luster AD, Acharya KR, Structure. 2003 May;11(5):521-32. PMID:12737818

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