1o83: Difference between revisions

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[[Image:1o83.jpg|left|200px]]
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{{STRUCTURE_1o83|  PDB=1o83  |  SCENE=  }}  
{{STRUCTURE_1o83|  PDB=1o83  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF BACTERIOCIN AS-48 AT PH 7.5, PHOSPHATE BOUND. CRYSTAL FORM I'''
===CRYSTAL STRUCTURE OF BACTERIOCIN AS-48 AT PH 7.5, PHOSPHATE BOUND. CRYSTAL FORM I===




==Overview==
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The bacteriocin AS-48 is a membrane-interacting peptide, which displays a broad anti-microbial spectrum against Gram-positive and Gram-negative bacteria. The NMR structure of AS-48 at pH 3 has been solved. The analysis of this structure suggests that the mechanism of AS-48 anti-bacterial activity involves the accumulation of positively charged molecules at the membrane surface leading to a disruption of the membrane potential. Here, we report the high-resolution crystal structure of AS-48 and sedimentation equilibrium experiments showing that this bacteriocin is able to adopt different oligomeric structures according to the physicochemical environment. The analysis of these structures suggests a mechanism for molecular function of AS-48 involving a transition from a water-soluble form to a membrane-bound state upon membrane binding.
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{{ABSTRACT_PUBMED_14623193}}


==About this Structure==
==About this Structure==
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[[Category: Protein crystallography]]
[[Category: Protein crystallography]]
[[Category: Protein membrane interaction]]
[[Category: Protein membrane interaction]]
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