1pfq: Difference between revisions
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New page: left|200px<br /> <applet load="1pfq" size="450" color="white" frame="true" align="right" spinBox="true" caption="1pfq, resolution 1.90Å" /> '''crystal structure o... |
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[[Image:1pfq.gif|left|200px]]<br /> | [[Image:1pfq.gif|left|200px]]<br /><applet load="1pfq" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="1pfq" size=" | |||
caption="1pfq, resolution 1.90Å" /> | caption="1pfq, resolution 1.90Å" /> | ||
'''crystal structure of human apo dipeptidyl peptidase IV / CD26'''<br /> | '''crystal structure of human apo dipeptidyl peptidase IV / CD26'''<br /> | ||
==Overview== | ==Overview== | ||
Dipeptidyl peptidase IV is a multifunctional type II transmembrane serine | Dipeptidyl peptidase IV is a multifunctional type II transmembrane serine protease glycoprotein. The high-resolution crystal structure of the homodimeric human apo dipeptidyl peptidase IV has been determined at 1.9 A resolution. In addition, the structure of the binary complex with 1-[([2-[(5-iodopyridin-2-yl)amino]-ethyl]amino)-acetyl]-2-cyano-(S)-pyrrol idine has been solved, revealing the nature of the covalent interaction with the active-site serine. | ||
==About this Structure== | ==About this Structure== | ||
1PFQ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NAG as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] Full crystallographic information is available from [http:// | 1PFQ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAG:'>NAG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PFQ OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Arcy, A | [[Category: Arcy, A D.]] | ||
[[Category: Dale, G | [[Category: Dale, G E.]] | ||
[[Category: Gardiner, R.]] | [[Category: Gardiner, R.]] | ||
[[Category: Oefner, C.]] | [[Category: Oefner, C.]] | ||
[[Category: Pierau, S.]] | [[Category: Pierau, S.]] | ||
[[Category: Sweeney, A | [[Category: Sweeney, A Mac.]] | ||
[[Category: NAG]] | [[Category: NAG]] | ||
[[Category: mch_1]] | [[Category: mch_1]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:28:19 2008'' | ||
