1od1: Difference between revisions

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[[Image:1od1.jpg|left|200px]]
{{Seed}}
[[Image:1od1.png|left|200px]]


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{{STRUCTURE_1od1|  PDB=1od1  |  SCENE=  }}  
{{STRUCTURE_1od1|  PDB=1od1  |  SCENE=  }}  


'''ENDOTHIAPEPSIN PD135,040 COMPLEX'''
===ENDOTHIAPEPSIN PD135,040 COMPLEX===




==Overview==
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The crystal structure of endothiapepsin complexed with the gem-diol inhibitor PD-135,040 has been anisotropically refined to a resolution of 1.37 A. The structure of this inhibitor complex is in agreement with previous structures of endothiapepsin gem-diol inhibitor complexes that have been used to develop proposed catalytic mechanisms. However, the increase in resolution over previous structures confirms the presence of a number of short hydrogen bonds within the active site that are likely to play an important role in the catalytic mechanism. The presence of low-barrier hydrogen bonds was indicated in a previous one-dimensional H NMR spectrum.
The line below this paragraph, {{ABSTRACT_PUBMED_12777758}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_12777758}}


==About this Structure==
==About this Structure==
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[[Category: Wood, S P.]]
[[Category: Wood, S P.]]
[[Category: Hydrolase,acid proteinase,inhibitor,aspartyl protease]]
[[Category: Hydrolase,acid proteinase,inhibitor,aspartyl protease]]
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