5y1i: Difference between revisions
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== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/ | [https://www.uniprot.org/uniprot/GFSF_STRHA GFSF_STRHA] Involved in the synthesis of the 16-membered macrolide antibiotics FD-891 and FD-892 (PubMed:20589823, PubMed:26630077, PubMed:28869713). Consecutively catalyzes epoxidation of C8-C9 and then hydroxylation at C10 to convert 25-O-methyl-FD-892 to FD-891 (PubMed:20589823). Consecutively catalyzes epoxidation of C8-C9 and then hydroxylation at C10 to convert 8,9-epoxy-FD-892 to 25-O-demethyl-FD-891 as well as converting 25-oxo-FD-892 to 8,9-epoxy-25-oxo-FD-892 and 8,9-epoxy-10-hydroxy-25-oxo-FD-892 (PubMed:26630077). In vitro is furnished with P.putida putidaredoxin and putidaredoxin reductase to provide the required two-electron reduction (PubMed:20589823, PubMed:26630077, PubMed:28869713).<ref>PMID:20589823</ref> <ref>PMID:26630077</ref> <ref>PMID:28869713</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
