1oe5: Difference between revisions

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[[Image:1oe5.gif|left|200px]]
{{Seed}}
[[Image:1oe5.png|left|200px]]


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{{STRUCTURE_1oe5|  PDB=1oe5  |  SCENE=  }}  
{{STRUCTURE_1oe5|  PDB=1oe5  |  SCENE=  }}  


'''XENOPUS SMUG1, AN ANTI-MUTATOR URACIL-DNA GLYCOSYLASE'''
===XENOPUS SMUG1, AN ANTI-MUTATOR URACIL-DNA GLYCOSYLASE===




==Overview==
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Cytosine deamination is a major promutagenic process, generating G:U mismatches that can cause transition mutations if not repaired. Uracil is also introduced into DNA via nonmutagenic incorporation of dUTP during replication. In bacteria, uracil is excised by uracil-DNA glycosylases (UDG) related to E. coli UNG, and UNG homologs are found in mammals and viruses. Ung knockout mice display no increase in mutation frequency due to a second UDG activity, SMUG1, which is specialized for antimutational uracil excision in mammalian cells. Remarkably, SMUG1 also excises the oxidation-damage product 5-hydroxymethyluracil (HmU), but like UNG is inactive against thymine (5-methyluracil), a chemical substructure of HmU. We have solved the crystal structure of SMUG1 complexed with DNA and base-excision products. This structure indicates a more invasive interaction with dsDNA than observed with other UDGs and reveals an elegant water displacement/replacement mechanism that allows SMUG1 to exclude thymine from its active site while accepting HmU.
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{{ABSTRACT_PUBMED_12820976}}


==About this Structure==
==About this Structure==
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[[Category: Single stranded]]
[[Category: Single stranded]]
[[Category: Smug1]]
[[Category: Smug1]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 03:43:54 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:58:36 2008''

Revision as of 06:58, 29 July 2008

File:1oe5.png

Template:STRUCTURE 1oe5

XENOPUS SMUG1, AN ANTI-MUTATOR URACIL-DNA GLYCOSYLASE

Template:ABSTRACT PUBMED 12820976

About this Structure

1OE5 is a Protein complex structure of sequences from Xenopus laevis. Full crystallographic information is available from OCA.

Reference

Structure and specificity of the vertebrate anti-mutator uracil-DNA glycosylase SMUG1., Wibley JE, Waters TR, Haushalter K, Verdine GL, Pearl LH, Mol Cell. 2003 Jun;11(6):1647-59. PMID:12820976

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