1oeb: Difference between revisions

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[[Image:1oeb.gif|left|200px]]
{{Seed}}
[[Image:1oeb.png|left|200px]]


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{{STRUCTURE_1oeb|  PDB=1oeb  |  SCENE=  }}  
{{STRUCTURE_1oeb|  PDB=1oeb  |  SCENE=  }}  


'''MONA/GADS SH3C DOMAIN'''
===MONA/GADS SH3C DOMAIN===




==Overview==
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SH3 domains are protein recognition modules within many adaptors and enzymes. With more than 500 SH3 domains in the human genome, binding selectivity is a key issue in understanding the molecular basis of SH3 domain interactions. The Grb2-like adaptor protein Mona/Gads associates stably with the T-cell receptor signal transducer SLP-76. The crystal structure of a complex between the C-terminal SH3 domain (SH3C) of Mona/Gads and a SLP-76 peptide has now been solved to 1.7 A. The peptide lacks the canonical SH3 domain binding motif P-x-x-P and does not form a frequently observed poly-proline type II helix. Instead, it adopts a clamp-like shape around the circumfence of the SH3C beta-barrel. The central R-x-x-K motif of the peptide forms a 3(10) helix and inserts into a negatively charged double pocket on the SH3C while several other residues complement binding through hydrophobic interactions, creating a short linear SH3C binding epitope of uniquely high affinity. Interestingly, the SH3C displays ion-dependent dimerization in the crystal and in solution, suggesting a novel mechanism for the regulation of SH3 domain functions.
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{{ABSTRACT_PUBMED_12773374}}


==About this Structure==
==About this Structure==
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[[Category: Signal tranduction]]
[[Category: Signal tranduction]]
[[Category: Slp-76]]
[[Category: Slp-76]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:54:16 2008''

Revision as of 10:54, 28 July 2008

File:1oeb.png

Template:STRUCTURE 1oeb

MONA/GADS SH3C DOMAIN

Template:ABSTRACT PUBMED 12773374

About this Structure

1OEB is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural basis for SH3 domain-mediated high-affinity binding between Mona/Gads and SLP-76., Harkiolaki M, Lewitzky M, Gilbert RJ, Jones EY, Bourette RP, Mouchiroud G, Sondermann H, Moarefi I, Feller SM, EMBO J. 2003 Jun 2;22(11):2571-82. PMID:12773374

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