1ogc: Difference between revisions

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[[Image:1ogc.gif|left|200px]]
{{Seed}}
[[Image:1ogc.png|left|200px]]


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{{STRUCTURE_1ogc|  PDB=1ogc  |  SCENE=  }}  
{{STRUCTURE_1ogc|  PDB=1ogc  |  SCENE=  }}  


'''THE STRUCTURE OF BACILLUS SUBTILIS RBSD COMPLEXED WITH D-RIBOSE'''
===THE STRUCTURE OF BACILLUS SUBTILIS RBSD COMPLEXED WITH D-RIBOSE===




==Overview==
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RbsD is the only protein whose biochemical function is unknown among the six gene products of the rbs operon involved in the active transport of ribose. FucU, a paralogue of RbsD conserved from bacteria to human, is also the only protein whose function is unknown among the seven gene products of the l-fucose regulon. Here we report the crystal structures of Bacillus subtilis RbsD, which reveals a novel decameric toroidal assembly of the protein. Nuclear magnetic resonance and other studies on RbsD reveal that the intersubunit cleft of the protein binds specific forms of d-ribose, but it does not have an enzyme activity toward the sugar. Likewise, FucU binds l-fucose but lacks an enzyme activity toward this sugar. We conclude that RbsD and FucU are cytoplasmic sugar-binding proteins, a novel class of proteins whose functional role may lie in helping influx of the sugar substrates.
The line below this paragraph, {{ABSTRACT_PUBMED_12738765}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_12738765}}


==About this Structure==
==About this Structure==
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[[Category: Sugar transport]]
[[Category: Sugar transport]]
[[Category: Transport]]
[[Category: Transport]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 03:48:34 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:13:58 2008''

Revision as of 11:14, 28 July 2008

File:1ogc.png

Template:STRUCTURE 1ogc

THE STRUCTURE OF BACILLUS SUBTILIS RBSD COMPLEXED WITH D-RIBOSE

Template:ABSTRACT PUBMED 12738765

About this Structure

1OGC is a Single protein structure of sequence from Bacillus subtilis. Full crystallographic information is available from OCA.

Reference

Crystal structures of RbsD leading to the identification of cytoplasmic sugar-binding proteins with a novel folding architecture., Kim MS, Shin J, Lee W, Lee HS, Oh BH, J Biol Chem. 2003 Jul 25;278(30):28173-80. Epub 2003 May 8. PMID:12738765

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