1ohc: Difference between revisions

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[[Image:1ohc.jpg|left|200px]]
{{Seed}}
[[Image:1ohc.png|left|200px]]


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{{STRUCTURE_1ohc|  PDB=1ohc  |  SCENE=  }}  
{{STRUCTURE_1ohc|  PDB=1ohc  |  SCENE=  }}  


'''STRUCTURE OF THE PROLINE DIRECTED PHOSPHATASE CDC14'''
===STRUCTURE OF THE PROLINE DIRECTED PHOSPHATASE CDC14===




==Overview==
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The Cdc14 family of dual-specificity protein phosphatases (DSPs) is conserved within eukaryotes and functions to down-regulate mitotic Cdk activities, promoting cytokinesis and mitotic exit. We have integrated structural and kinetic analyses to define the molecular mechanism of the dephosphorylation reaction catalysed by Cdc14. The structure of Cdc14 illustrates a novel arrangement of two domains, each with a DSP-like fold, arranged in tandem. The C-terminal domain contains the conserved PTP motif of the catalytic site, whereas the N-terminal domain, which shares no sequence similarity with other DSPs, contributes to substrate specificity, and lacks catalytic activity. The catalytic site is located at the base of a pronounced surface channel formed by the interface of the two domains, and regions of both domains interact with the phosphopeptide substrate. Specificity for a pSer-Pro motif is mediated by a hydrophobic pocket that is capable of accommodating the apolar Pro(P+1) residue of the peptide. Our structural and kinetic data support a role for Cdc14 in the preferential dephosphorylation of proteins modified by proline-directed kinases.
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{{ABSTRACT_PUBMED_12853468}}


==About this Structure==
==About this Structure==
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[[Category: Dual specificity phosphatase]]
[[Category: Dual specificity phosphatase]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 03:50:51 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:11:49 2008''

Revision as of 01:11, 29 July 2008

File:1ohc.png

Template:STRUCTURE 1ohc

STRUCTURE OF THE PROLINE DIRECTED PHOSPHATASE CDC14

Template:ABSTRACT PUBMED 12853468

About this Structure

1OHC is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structure of the cell cycle protein Cdc14 reveals a proline-directed protein phosphatase., Gray CH, Good VM, Tonks NK, Barford D, EMBO J. 2003 Jul 15;22(14):3524-35. PMID:12853468

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