8qe9: Difference between revisions
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==Complex between the 80a-Sak SSAP and the SaPI2 Stl master regulator== | |||
<StructureSection load='8qe9' size='340' side='right'caption='[[8qe9]], [[Resolution|resolution]] 3.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8qe9]] is a 64 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus] and [https://en.wikipedia.org/wiki/Staphylococcus_phage_80alpha Staphylococcus phage 80alpha]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8QE9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8QE9 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.9Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8qe9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8qe9 OCA], [https://pdbe.org/8qe9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8qe9 RCSB], [https://www.ebi.ac.uk/pdbsum/8qe9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8qe9 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/A0FIL5_STAAU A0FIL5_STAAU] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Bacteria often carry multiple genes encoding anti-phage defense systems, clustered in defense islands and phage satellites. Various unrelated anti-phage defense systems target phage-encoded homologous recombinases (HRs) through unclear mechanisms. Here, we show that the phage satellite SaPI2, which does not encode orthodox anti-phage defense systems, provides antiviral immunity mediated by Stl2, the SaPI2-encoded transcriptional repressor. Stl2 targets and inhibits phage-encoded HRs, including Sak and Sak4, two HRs from the Rad52-like and Rad51-like superfamilies. Remarkably, apo Stl2 forms a collar of dimers oligomerizing as closed rings and as filaments, mimicking the quaternary structure of its targets. Stl2 decorates both Sak rings and Sak4 filaments. The oligomerization of Stl2 as a collar of dimers is necessary for its inhibitory activity both in vitro and in vivo. Our results shed light on the mechanisms underlying antiviral immunity against phages carrying divergent HRs. | |||
Phage parasites targeting phage homologous recombinases provide antiviral immunity.,Debiasi-Anders G, Qiao C, Salim A, Li N, Mir-Sanchis I Nat Commun. 2025 Feb 22;16(1):1889. doi: 10.1038/s41467-025-57156-3. PMID:39987160<ref>PMID:39987160</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 8qe9" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Staphylococcus aureus]] | |||
[[Category: Staphylococcus phage 80alpha]] | |||
[[Category: Debiasi-Anders G]] | |||
[[Category: Mir-Sanchis I]] | |||
Latest revision as of 07:54, 5 March 2025
Complex between the 80a-Sak SSAP and the SaPI2 Stl master regulator
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